Product overview

Name NS 309
Purity >98%
Description Potent, selective KCa3.1 / KCa2 channel subfamily activator
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Biological Data

Biological description Potent and selective KCa3.1 channel and KCa2 channel subfamily activator (EC50 = 0.3 µM for KCa2.3). Exhibits little or no activity at KCa1.1 channels. Displays >1000 fold higher potency than 1-EBIO.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name 6,7-Dichloro-1H-indole-2,3-dione 3-oxime
Molecular Weight 231.04
Chemical structure NS 309  [18711-16-5] Chemical Structure
Molecular Formula C8H4Cl2N2O2
CAS Number 18711-16-5
PubChem identifier 11637204
SMILES ClC1=C2C(C(C(N2)=O)=NO)=CC=C1Cl
InChiKey CVOUSAVHMDXCKG-UHFFFAOYSA-N

References for NS 309

References are publications that support the biological activity of the product
  • NS309 decreases rat detrusor smooth muscle membrane potential and phasic contractions by activating SK3 channels.

    Parajuli SP et al (2013) Br J Pharmacol 168(7) : 1611-25.
  • Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels.

    Hougaard C et al (2007) Br J Pharmacol 151(5) : 655-65.
  • Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime).

    Strøbaek D et al (2004) Biochim Biophys Acta 1665(1-2) : 1-5.

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