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NSC 33994


Product overview

  • Name
    NSC 33994
  • Short description
    Potent, selective JAK2 inhibitor
  • Biological description
    Potent and selective JAK2 inhibitor (IC50 = 60 nM). Shows anti-neoplastic actions.
  • Alternative names
  • Biological action
  • Purity
  • Citations


  • Chemical name
  • Molecular Weight
  • Chemical structure
    NSC 33994  [82058-16-0]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (5mM, gentle warming) or ethanol (10mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for NSC 33994

  • Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening.

    Kiss R et al (2009) Bioorg Med Chem Lett 19(13) : 3598-601.
    PubMedID: 19447617
  • The Jak2 small molecule inhibitor, G6, reduces the tumorigenic potential of T98G glioblastoma cells in vitro and in vivo.

    Baskin R et al (2014) PLoS One 9(8) : e105568.
    PubMedID: 25162558
  • The Jak2 inhibitor, G6, alleviates Jak2-V617F-mediated myeloproliferative neoplasia by providing significant therapeutic efficacy to the bone marrow.

    Kirabo A et al (2011) Neoplasia 13(11) : 1058-68.
    PubMedID: 22131881
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