Product overview

Name NSC 33994
Alternative names G6
Purity >98%
Description Potent, selective JAK2 inhibitor
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Biological Data

Biological description Potent and selective JAK2 inhibitor (IC50 = 60 nM). Shows anti-neoplastic actions.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (5mM, gentle warming) or ethanol (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >98%
Chemical name E-4,4'-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]phenol
Molecular Weight 438.65
Chemical structure NSC 33994  [82058-16-0] Chemical Structure
Molecular Formula C28H42N2O2
CAS Number 82058-16-0
PubChem identifier 5473838
SMILES CC/C(C2=CC=C(O)C(CN(CC)CC)=C2)=C(CC)\C1=CC(CN(CC)CC)=C(O)C=C1
InChiKey QFNJFVBKASKGEU-OCEACIFDSA-N

References for NSC 33994

References are publications that support the biological activity of the product
  • The Jak2 small molecule inhibitor, G6, reduces the tumorigenic potential of T98G glioblastoma cells in vitro and in vivo.

    Baskin R et al (2014) PLoS One 9(8) : e105568.
  • The Jak2 inhibitor, G6, alleviates Jak2-V617F-mediated myeloproliferative neoplasia by providing significant therapeutic efficacy to the bone marrow.

    Kirabo A et al (2011) Neoplasia 13(11) : 1058-68.
  • Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening.

    Kiss R et al (2009) Bioorg Med Chem Lett 19(13) : 3598-601.

3 Item(s)