Product overview

  • Name
    NSC 3852
  • Short description
    Non-selective HDAC inhibitor
  • Biological description
    Non-selective histone deacetylase (HDAC) inhibitor. Causes reactive oxygen species release and damages DNA. Shows anti-proliferative, apoptotic, anti-cancer and anti-protozoal actions.
  • Alternative names
    5-nitroso-8-quinolinol
  • Biological action
    Inhibitor
  • Our products in action

Properties

  • Chemical name
    5-Nitroso-8-quinolinol
  • Molecular Weight
    174.16
  • Chemical structure
    NSC 3852  [3565-26-2]
  • Molecular Formula
    C9H6N2O2
  • CAS Number
    3565-26-2

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (10mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for NSC 3852

  • Differentiation-inducing quinolines as experimental breast cancer agents in the MCF-7 human breast cancer cell model.

    Martirosyan AR et al (2004) Biochem Pharmacol 68(9) : 1729-38.
    PubMedID: 15450938
  • Actions of a histone deacetylase inhibitor NSC3852 (5-nitroso-8-quinolinol) link reactive oxygen species to cell differentiation and apoptosis in MCF-7 human mammary tumor cells.

    Martirosyan A et al (2006) J Pharmacol Exp Ther 317(2) : 546-52.
    PubMedID: 16497787
  • Inhibition of Toxoplasma gondii and Plasmodium falciparum infections in vitro by NSC3852, a redox active antiproliferative and tumor cell differentiation agent.

    Strobl JS et al (2009) J Parasitol 95(1) : 215-23.
    PubMedID: 18837587

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