NSC 74859

(HB1436)

Product overview

  • Name
    NSC 74859
  • Short description
    Selective STAT3 inhibitor
  • Biological description
    Selective STAT3 DNA-binding inhibitor. Selectively inhibits STAT3-STAT3 over STAT1-STAT3 and STAT1-STAT1 DNA-binding (IC50 values are 86, 160 and >300 µM respectively). Enhances the activity of cytotoxic drugs. Shows antiproliferative, apoptotic and anti-tumor actions.
  • Alternative names
    S3I-201
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    2-Hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoic acid
  • Molecular Weight
    365.36
  • Chemical structure
    NSC 74859  [501919-59-1]
  • Molecular Formula
    C16H15NO7S
  • CAS Number
    501919-59-1

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in DMSO (10mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for NSC 74859

  • Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity.

    Siddiquee K et al (2007) Proc Natl Acad Sci U S A 104(18) : 7391-6.
    PubMedID: 17463090
  • NSC 74859-mediated inhibition of STAT3 enhances the anti-proliferative activity of cetuximab in hepatocellular carcinoma.

    Chen W et al (2012) Liver Int 32(1) : 70-7.
    PubMedID: 22098470
  • NSC 74859 enhances doxorubicin cytotoxicity via inhibition of epithelial-mesenchymal transition in hepatocellular carcinoma cells.

    Hu QD et al (2012) Cancer Lett 325(2) : 207-13.
    PubMedID: 22781398

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