Product overview

Name NSC 74859
Alternative names S3I-201
Purity >98%
Description Selective STAT3 inhibitor
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Biological Data

Biological description Selective STAT3 DNA-binding inhibitor. Selectively inhibits STAT3-STAT3 over STAT1-STAT3 and STAT1-STAT1 DNA-binding (IC50 values are 86, 160 and >300 µM respectively). Enhances the activity of cytotoxic drugs. Shows antiproliferative, apoptotic and anti-tumor actions.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >98%
Chemical name 2-Hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoic acid
Molecular Weight 365.36
Chemical structure NSC 74859  [501919-59-1] Chemical Structure
Molecular Formula C16H15NO7S
CAS Number 501919-59-1
PubChem identifier 252682
SMILES CC1=CC=C(S(OCC(NC2=CC=C(C(O)=O)C(O)=C2)=O)(=O)=O)C=C1
InChiKey HWNUSGNZBAISFM-UHFFFAOYSA-N

References for NSC 74859

References are publications that support the biological activity of the product
  • NSC 74859-mediated inhibition of STAT3 enhances the anti-proliferative activity of cetuximab in hepatocellular carcinoma.

    Chen W et al (2012) Liver Int 32(1) : 70-7.
  • NSC 74859 enhances doxorubicin cytotoxicity via inhibition of epithelial-mesenchymal transition in hepatocellular carcinoma cells.

    Hu QD et al (2012) Cancer Lett 325(2) : 207-13.
  • Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity.

    Siddiquee K et al (2007) Proc Natl Acad Sci U S A 104(18) : 7391-6.

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