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Data

Product overview

  • Name
    ODQ
  • Short description
    Potent, selective guanylyl cyclase inhibitor
  • Biological description
    Potent, selective guanylyl cyclase inhibitor (IC50 = ~20 nM). Shows anxiolytic and anti-tumour actions. Also shows potential memory disturbing effects.
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
  • Molecular Weight
    187.16
  • Chemical structure
    ODQ [41443-28-1]
  • Molecular Formula
    C9H5N3O2
  • CAS Number
    41443-28-1
  • PubChem identifier
    1456
  • SMILES
    C1=CC=C2C(=C1)N=CC3=NOC(=O)N23
  • Source
    Synthetic
  • InChi
    InChI=1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H
  • InChiKey
    LZMHWZHOZLVYDL-UHFFFAOYSA-N
  • MDL number
    MFCD00792620
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in DMSO (100mM) and in ethanol (20 mM, gentle warming)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for ODQ

  • Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase.

    Boulton et al (1995) Neuroscienec 69(3) : 699-703
    PubMedID: 8596640
  • In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway.

    Fedele et al (1996) Br J Pharmacol 119(3) : 590-4
    PubMedID: 8894183
  • Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.

    Garthwaite et al (1995) Moll Pharmacol 48(2) : 184-8
    PubMedID: 7544433
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