ODQ
(HB2900)
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Code: HB0443
Pack: 1mg,10mg,50mg,50mM (add 1ml water),100mM (add 1ml water)
Code: HB0225
Pack: 1mg,10mg,50mg,100mg,50mM (add 1ml water),100mM (add 1ml water)
Code: HB2096
Pack: 10mg,50mg
ODQ
(HB2900)- Data
- Support & Resources
Product overview
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Name
ODQ
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Short description
Potent, selective guanylyl cyclase inhibitor
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Biological description
Potent, selective guanylyl cyclase inhibitor (IC50 = ~20 nM). Shows anxiolytic and anti-tumour actions. Also shows potential memory disturbing effects.
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Purity
>98%
- Citations
Properties
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Chemical name
1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
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Molecular Weight
187.16
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Chemical structure
![ODQ [41443-28-1]](data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs= "ODQ [41443-28-1]")
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Molecular Formula
C9H5N3O2
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CAS Number
41443-28-1
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PubChem identifier
1456
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SMILES
C1=CC=C2C(=C1)N=CC3=NOC(=O)N23
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Source
Synthetic
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InChi
InChI=1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H
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InChiKey
LZMHWZHOZLVYDL-UHFFFAOYSA-N
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MDL number
MFCD00792620
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Appearance
White solid
![ODQ [41443-28-1]](https://www.hellobio.com/media/catalog/product/cache/1/image/9df78eab33525d08d6e5fb8d27136e95/h/b/hb2900.png "ODQ [41443-28-1]")
Storing and Using Your Product
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Storage instructions
+4°C
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Solubility overview
Soluble in DMSO (100mM) and in ethanol (20 mM, gentle warming)
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Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for ODQ
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Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase.
Boulton et al (1995) Neuroscienec 69(3) : 699-703PubMedID: 8596640 -
In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway.
Fedele et al (1996) Br J Pharmacol 119(3) : 590-4PubMedID: 8894183 -
Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.
Garthwaite et al (1995) Moll Pharmacol 48(2) : 184-8PubMedID: 7544433
Reviews & Product Guides
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