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Biological Data

Biological description Potent, selective guanylyl cyclase inhibitor (IC50 = ~20 nM). Shows anxiolytic and anti-tumour actions. Also shows potential memory disturbing effects.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM) and in ethanol (20 mM, gentle warming)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
Molecular Weight 187.16
Chemical structure ODQ [41443-28-1] Chemical Structure
Molecular Formula C9H5N3O2
CAS Number 41443-28-1
PubChem identifier 1456
SMILES C1=CC=C2C(=C1)N=CC3=NOC(=O)N23
Source Synthetic
InChi InChI=1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H
InChiKey LZMHWZHOZLVYDL-UHFFFAOYSA-N
MDL number MFCD00792620
Appearance White solid

References for ODQ

References are publications that support the biological activity of the product
  • In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway.

    Fedele et al (1996) Br J Pharmacol 119(3) : 590-4
  • Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase.

    Boulton et al (1995) Neuroscienec 69(3) : 699-703
  • Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.

    Garthwaite et al (1995) Moll Pharmacol 48(2) : 184-8

3 Item(s)