Okadaic Acid Sodium Salt

(HB0470)

Product overview

  • Name
    Okadaic Acid Sodium Salt
  • Short description
    Water soluble, potent protein phosphatase 1 and 2A inhibitor
  • Biological description
    Water soluble. Potent protein phosphatase 1 (PP1) and 2A (PP2A) inhibitor (IC50 values are 3 and 0.2-1 nM). Found in the black sponge Halichondria okadai. Mimics effects of insulin on glucose transport in adipocytes. Displays tumour promoting properties.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Molecular Weight
    827
  • Chemical structure
    Okadaic Acid Sodium Salt  [209266-80-8]
  • Molecular Formula
    C44H67O13Na
  • CAS Number
    209266-80-8
  • PubChem identifier
    23714931
  • SMILES
    CC1CC[C@]2(CCCCO2)O[C@@H]1[C@@H](C)C[C@@H]([C@@H]3C(=C)[C@H]([C@H]4[C@H](O3)CC[C@]5(O4)CC[C@@H](O5)/C=C/[C@@H](C)[C@@H]6CC(=C[C@@]7(O6)[C@@H](CC[C@H](O7)C[C@](C)(C(=O)[O-])O)O)C)O)O.[Na+]

Storing and Using Your Product

  • Solubility overview
    soluble in DMSO (1mg/ml) or ethanol
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Okadaic Acid Sodium Salt

  • Okadaic acid: a new probe for the study of cellular regulation.

    Cohen P et al (1990) Trends Biochem Sci 15(3) : 98-102.
    PubMedID: 2158158
  • Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics.

    Bialojan C et al (1988) Biochem J 256(1) : 283-90.
    PubMedID: 2851982
  • Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism.

    Haystead TA et al (1989) Nature 337(6202) : 78-81.
    PubMedID: 2562908

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