Okadaic Acid

(HB0468)

Product overview

  • Name
    Okadaic Acid
  • Short description
    Potent, non-competitive protein phosphatase inhibitor
  • Biological description
    Potent and non-competitive protein phosphatase inhibitor. Exhibits higher selectivity for PP2A and PP1 over PCM (purified polycation-modulated) phosphatase and PP2B (ID50 values are 1.2, 315, 205 and 4530 nM respectively) yet little or no activity at PP2C. Displays apoptosis inducing properties with neurotoxic and tumor promoting effects. A diarrheic shellfish poisoning (DSP) toxin.
  • Alternative names
    OA
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    9,10-Deepithio-9,10-didehydroacanthifolicin
  • Molecular Weight
    805.01
  • Chemical structure
    Okadaic Acid  [78111-17-8]
  • Molecular Formula
    C44H68O13
  • CAS Number
    78111-17-8
  • PubChem identifier
    446512
  • SMILES
    C[C@@H]1CC[C@]2(CCCCO2)O[C@@H]1[C@@H](C)C[C@@H]([C@@H]3C(=C)[C@H]([C@H]4[C@H](O3)CC[C@]5(O4)CC[C@@H](O5)/C=C/[C@@H](C)[C@@H]6CC(=C[C@@]7(O6)[C@@H](CC[C@H](O7)C[C@](C)(C(=O)O)O)O)C)O)O
  • InChi
    InChI=1S/C44H68O13/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,
  • InChiKey
    QNDVLZJODHBUFM-WFXQOWMNSA-N
  • MDL number
    MFCD00083455

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    Soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Okadaic Acid

  • Okadaic acid activates the PKR pathway and induces apoptosis through PKR stimulation in MG63 osteoblast-like cells.

    Haneji T et al (2013) Int J Oncol 42(6) : 1904-10.
    PubMedID: 23591640
  • Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics.

    Bialojan C et al (1988) Biochem J 256(1) : 283-90.
    PubMedID: 2851982
  • Okadaic acid activates atypical protein kinase C (zeta/lambda) in rat and 3T3/L1 adipocytes. An apparent requirement for activation of Glut4 translocation and glucose transport.

    Standaert ML et al (1999) J Biol Chem 274(20) : 14074-8.
    PubMedID: 10318822
  • Okadaic acid: more than a diarrheic toxin.

    Valdiglesias V et al (2013) Mar Drugs 11(11) : 4328-49.
    PubMedID: 24184795

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