ω-Agatoxin IVA

(HB1212)

Product overview

  • Name
    ω-Agatoxin IVA
  • Short description
    Potent, selective P-type / Q-type Ca2+ channel blocker
  • Biological description
    Potent and selective P-type / Q-type Ca2+ channel blocker (IC50 = <1-3 nM for P type channels). Exhibits reduced potency at N-type Ca2+ channels. Found in the venom of the funnel web spider Agelenopsis aperta.
  • Biological action
    Blocker
  • Citations

Properties

  • Chemical name
    H-DL-Lys-DL-Lys-DL-Lys-DL-Cys(1)-DL-xiIle-DL-Ala-DL-Lys-DL-Asp-DL-Tyr-Gly-DL-Arg-DL-Cys(2)-DL-Lys-DL-Trp-Gly-Gly-DL-xiThr-DL-Pro-DL-Cys(3)-DL-Cys(1)-DL-Arg-Gly-DL-Arg-Gly-DL-Cys(2)-DL-xiIle-DL-Cys(4)-DL-Ser-DL-xiIle-DL-Met-Gly-DL-xiThr-DL-Asn-DL-Cys(4)-DL-Glu-DL-Cys(3)-DL-Lys-DL-Pro-DL-Arg-DL-Leu-DL-xiIle-DL-Met-DL-Glu-Gly-DL-Leu-Gly-DL-Leu-DL-Ala-OH
  • Molecular Weight
    5202.25
  • Molecular Formula
    C217H360N68O60S10
  • CAS Number
    145017-83-0
  • PubChem identifier
    90488780
  • SMILES
    CCC(C)C1C(=O)NC2CSSCC(C(=O)NC(C(=O)NC(CSSCC3C(=O)NC4CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(CSSCC(C(=O)N1)NC(=O)CNC(=O)C(NC(=O)CNC(=O)C(NC4=O)CCCNC(=N)N)CCCNC(=N)N)C(=O)NC(C(=O)NC(C(=O)NCC(=O)NCC(=O)NC(C(=O)N5CCCC5C(=O)N3)C(C)O)CC6=CNC7=CC=CC=C76)CCCCN)CCCNC(=N)N)CC8=CC=C(C=C8)O)CC(=O)O)CCCCN)C)C(C)CC)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CCCCN)N)C(=O)NC(CCCCN)C(=O)N9CCCC9C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(CCSC)C(=O)NC(CCC(=O)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)O)CCC(=O)O)NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC2=O)CO)C(C)CC)CCSC)C(C)O)CC(=O)N
  • InChi
    InChI=1S/C217H360N68O60S10/c1-21-111(11)168-206(337)247-115(15)174(305)254-128(48-28-34-70-219)185(316)268-144(89-167(303)304)193(324)266-141(86-119-59-61-121(289)62-60-119)181(312)246-94-159(293)250-127(55-41-77-236-216(230)231)183(314)271-147-101-349-34
  • InChiKey
    NVVFOMZVLALQKT-UHFFFAOYSA-N
  • MDL number
    MFCD00165055

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    Soluble in water
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for ω-Agatoxin IVA

  • Synthesis of omega-agatoxin IVA and its related peptides.

    Nishio H et al (1993) Biochem Biophys Res Commun 196(3) : 1447-53.
    PubMedID: 8250902
  • Differential responses to ω-agatoxin IVA in murine frontal cortex and spinal cord derived neuronal networks.

    Knaack GL et al (2013) Neurotoxicology 37 : 19-25.
    PubMedID: 23523780
  • Protease treatment of cerebellar purkinje cells renders omega-agatoxin IVA-sensitive Ca2+ channels insensitive to inhibition by omega-conotoxin GVIA.

    Tringham EW et al (2008) J Pharmacol Exp Ther 324(2) : 806-14.
    PubMedID: 17975010

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