Product overview

Name ω-Agatoxin IVA
Alternative names ω-Aga-IV A
Purity >95%
Description

Potent, selective P-type / Q-type Ca2+ channel blocker

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Images

ω-Agatoxin IVA product vial image | Hello Bio

Biological Data

Biological description Potent and selective P-type / Q-type Ca2+ channel blocker (IC50 = <1-3 nM for P type channels). Exhibits reduced potency at N-type Ca2+ channels. Found in the venom of the funnel web spider Agelenopsis aperta.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Molecular Weight 5202.25
Chemical structure ω-Agatoxin IVA  [145017-83-0] Chemical Structure
Molecular Formula C217H360N68O60S10
CAS Number 145017-83-0
PubChem identifier 90488780
SMILES CCC(C)C1C(=O)NC2CSSCC(C(=O)NC(C(=O)NC(CSSCC3C(=O)NC4CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(CSSCC(C(=O)N1)NC(=O)CNC(=O)C(NC(=O)CNC(=O)C(NC4=O)CCCNC(=N)N)CCCNC(=N)N)C(=O)NC(C(=O)NC(C(=O)NCC(=O)NCC(=O)NC(C(=O)N5CCCC5C(=O)N3)C(C)O)CC6=CNC7=CC=CC=C76)CCCCN)CCCNC(=N)N)CC8=CC=C(C=C8)O)CC(=O)O)CCCCN)C)C(C)CC)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CCCCN)N)C(=O)NC(CCCCN)C(=O)N9CCCC9C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(CCSC)C(=O)NC(CCC(=O)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)O)CCC(=O)O)NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC2=O)CO)C(C)CC)CCSC)C(C)O)CC(=O)N
InChi InChI=1S/C217H360N68O60S10/c1-21-111(11)168-206(337)247-115(15)174(305)254-128(48-28-34-70-219)185(316)268-144(89-167(303)304)193(324)266-141(86-119-59-61-121(289)62-60-119)181(312)246-94-159(293)250-127(55-41-77-236-216(230)231)183(314)271-147-101-349-34
InChiKey NVVFOMZVLALQKT-UHFFFAOYSA-N
MDL number MFCD00165055

References for ω-Agatoxin IVA

References are publications that support the biological activity of the product
  • Differential responses to ω-agatoxin IVA in murine frontal cortex and spinal cord derived neuronal networks.

    Knaack GL et al (2013) Neurotoxicology 37 : 19-25.
  • Protease treatment of cerebellar purkinje cells renders omega-agatoxin IVA-sensitive Ca2+ channels insensitive to inhibition by omega-conotoxin GVIA.

    Tringham EW et al (2008) J Pharmacol Exp Ther 324(2) : 806-14.
  • Synthesis of omega-agatoxin IVA and its related peptides.

    Nishio H et al (1993) Biochem Biophys Res Commun 196(3) : 1447-53.

3 Item(s)

Publications
These publications cite the use of ω-Agatoxin IVA purchased from Hello Bio:
  • Calcium-induced calcium release activates spontaneous miniature outward currents in newt medullary reticular formation neurons

    Yaeger DB et al (2018) J Neurophysiol 120(6) : 3140-3154
    PubMedID: 29897864

1 Item