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ω-Agatoxin TK


Product overview

  • Name
    ω-Agatoxin TK
  • Short description
    Potent, selective P-type / Q-type Ca2+ channel blocker
  • Biological description
    Potent and selective P/Q-type Ca2+ channel blocker (IC50 = 127 nM for Q type channels). Displays little or no activity at L-type Ca2+ channels. Found in the venom of the funnel web spider Agelenopsis aperta.
  • Alternative names
    Agatoxin IVB
  • Biological action
  • Citations


  • Molecular Weight
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChiKey

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    soluble in water
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for ω-Agatoxin TK

  • Omega-agatoxin-TK containing D-serine at position 46, but not synthetic omega-[L-Ser46]agatoxin-TK, exerts blockade of P-type calcium channels in cerebellar Purkinje neurons.

    Kuwada M et al (1994) Mol Pharmacol 46(4) : 587-93.
    PubMedID: 7969037
  • High-affinity inhibition of glutamate release from corticostriatal synapses by omega-agatoxin TK.

    Barral J et al (2001) Eur J Pharmacol 430(2-3) : 167-73.
    PubMedID: 11711028
  • A novel type of calcium channel sensitive to omega-agatoxin-TK in cultured rat cerebral cortical neurons.

    Teramoto T et al (1997) Brain Res 756(1-2) : 225-30.
    PubMedID: 9187336
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