Oncrasin 1

(HB0473)

Product overview

  • Name
    Oncrasin 1
  • Short description
    Small molecule RNA polymerase II inhibitor
  • Biological description
    Small molecule RNA polymerase II inhibitor. Also induces dose-dependent cytotoxicity (IC50 = 4.81 µM) and disrupts interaction of PKCι and cyclin-dependent protein kinase 9/cyclin T1 complex. Anticancer agent that induces apoptosis. Displays antiproliferative properties.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    1-[(4-Chlorophenyl)methyl]-1H-indole-3-carboxaldehyde
  • Molecular Weight
    269.73
  • Chemical structure
    Oncrasin 1  [75629-57-1]
  • Molecular Formula
    C16H12ClNO
  • CAS Number
    75629-57-1

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (25mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Oncrasin 1

  • Analogues and derivatives of oncrasin-1, a novel inhibitor of the C-terminal domain of RNA polymerase II and their antitumor activities.

    Wu S et al (2011) J Med Chem 54(8) : 2668-79.
    PubMedID: 21443218
  • Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota.

    Guo W et al (2008) Cancer Res 68(18) : 7403-8.
    PubMedID: 18794128
  • Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1).

    Guo W et al (2009) Mol Cancer Ther 8(2) : 441-8.
    PubMedID: 19208825

Reviews & Product Guides