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Oncrasin 1


Product overview

  • Name
    Oncrasin 1
  • Short description
    Small molecule RNA polymerase II inhibitor
  • Biological description
    Small molecule RNA polymerase II inhibitor. Also induces dose-dependent cytotoxicity (IC50 = 4.81 µM) and disrupts interaction of PKCι and cyclin-dependent protein kinase 9/cyclin T1 complex. Anticancer agent that induces apoptosis. Displays antiproliferative properties.
  • Biological action
  • Purity
  • Citations


  • Chemical name
  • Molecular Weight
  • Chemical structure
    Oncrasin 1  [75629-57-1]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (25mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Oncrasin 1

  • Analogues and derivatives of oncrasin-1, a novel inhibitor of the C-terminal domain of RNA polymerase II and their antitumor activities.

    Wu S et al (2011) J Med Chem 54(8) : 2668-79.
    PubMedID: 21443218
  • Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota.

    Guo W et al (2008) Cancer Res 68(18) : 7403-8.
    PubMedID: 18794128
  • Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1).

    Guo W et al (2009) Mol Cancer Ther 8(2) : 441-8.
    PubMedID: 19208825
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