Ophiobolin A

(HB0474)

Product overview

  • Name
    Ophiobolin A
  • Short description
    Irreversible calmodulin antagonist
  • Biological description
    Irreversible calmodulin antagonist that reacts with lysine residues (IC50 0.87-3.7 µM). Also inhibits calcium-dependent human growth hormone (hGH) release (approx Ki = 10 µM). A membrane permeable fungal metabolite and a phytotoxin. Displays antitumor and apoptotic inducing properties.
  • Biological action
    Antagonist
  • Purity
    >95%
  • Citations

Properties

  • Chemical name
    Cochliobolin A
  • Molecular Weight
    400.6
  • Chemical structure
    Ophiobolin A  [988837]
  • Molecular Formula
    C25H36O4
  • CAS Number
    4611-05-6
  • PubChem identifier
    5281387
  • SMILES
    C[C@H]1C[C@@H](O[C@@]12CC[C@]3([C@H]2C/C=C([C@@H]4[C@H](C3)[C@](CC4=O)(C)O)/C=O)C)C=C(C)C

Storing and Using Your Product

  • Solubility overview
    soluble in DMSO or DMF
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Ophiobolin A

  • Ophiobolin A, a sesterterpenoid fungal phytotoxin, displays higher in vitro growth-inhibitory effects in mammalian than in plant cells and displays in vivo antitumor activity.

    Bury M et al (2013) Int J Oncol 43(2) : 575-85.
    PubMedID: 23754298
  • Identification of the binding and inhibition sites in the calmodulin molecule for ophiobolin A by site-directed mutagenesis.

    Kong Au T et al (1998) Plant Physiol 118(3) : 965-73.
    PubMedID: 9808741
  • Calmodulin and lipid binding to synaptobrevin regulates calcium-dependent exocytosis.

    Quetglas S et al (2002) EMBO J 21(15) : 3970-9.
    PubMedID: 12145198

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