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Orexin A (human, rat, mouse)

(HB2937)
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Technical documents: SDS CoA Datasheet

Product overview

Name Orexin A (human, rat, mouse)
Biological description

Overview

Excitatory neuropeptide at orexin receptors (Ki values are 20 and 38 nM for OX1 and OX2 receptors respectively).

Orexin-A is synthesized by a cluster of neurons in the lateral hypothalamus and perifornical area. Orexin A is composed of 33 amino acids.

Uses and applications

The peptide is involved in a variety of physiological functions. E.g. feeding behavior, sleep/wake rhythms, thermoregulation, energy metabolism and cardiovascular activity. More recently orexins have been suggested to have a role in emotional regulation, energetic homeostasis, reward mechanisms, drug addiction, arousal system, sleep and wakefulness.

Purity >95%
Description Excitatory neuropeptide at orexin OX1/OX2 receptors
Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (1 mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Chemical name XPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL (modifications: C-terminal amide; X-1 = Glp; Disulfide bonds: 6-12, 7-14)
Molecular Weight 3561.12
Chemical structure Orexin A (human, rat, mouse) | [205640-90-0] Chemical Structure
Molecular Formula C152H243N47O44S4
Sequence (one letter) XPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL
Modifications C-terminal amide; X-1 = Glp; Disulfide bonds: 6-12, 7-14
CAS Number 205640-90-0
PubChem identifier 56842143
SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CN=CN1)NC(=O)[C@H](CC(=O)N)NC(=O)CNC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]4CSSC[C@H]5C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N5)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]6CCCN6C(=O)[C@H](CC(C)C)NC(=O)[C@@H]7CCCN7C(=O)[C@@H]8CCC(=O)N8)C(=O)N[C@H](C(=O)N4)CO)[C@@H](C)O)CCCCN)CCC(=O)N)CCCNC(=N)N
InChiKey OFNHNCAUVYOTPM-IIIOAANCSA-N
MDL number MFCD01635374

References for Orexin A (human, rat, mouse)

References are publications that support the biological activity of the product

3 Item(s)

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Grouped product items
Order: HB2937
Pack PriceQty
100μg
$141
500μg
$348
1mg
$471
Excitatory neuropeptide at orexin OX1/OX2 receptors
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