Product overview

Name Orexin B (mouse)
Biological description Excitatory neuropeptide at orexin receptors (Ki values are 420 and 36 nM for OX1 and OX2 receptors respectively). Orexin B is involved in a many physiological functions (such as feeding regulation, sleep-wake cycle, energy metabolism etc.).
Alternative names Hypocretin-2
Purity >95%
Description Mouse excitatory neuropeptide at orexin OX1/OX2 receptors
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Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (1 mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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Dilution

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Chemical Data

Purity >95%
Chemical name RPGPPGLQGRLQRLLQANGNHAAGILTM (modifications: Met-28 = C-terminal amide)
Molecular Weight 2936.43
Chemical structure Orexin B (mouse) | [202801-92-1] Chemical Structure
Molecular Formula C126H215N45O34S
Sequence (one letter) RPGPPGLQGRLQRLLQANGNHAAGILTM
Modifications Met-28 = C-terminal amide
CAS Number 202801-92-1
PubChem identifier 90479795
SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CC(=O)N)NC(=O)CNC(=O)[C@H](CC(=O)N)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]3CCCN3C(=O)CNC(=O)[C@@H]4CCCN4C(=O)[C@H](CCCNC(=N)N)N
InChiKey RLVZFBVFVIDDPQ-GWQFQBPDSA-N
MDL number MFCD01635376

References for Orexin B (mouse)

References are publications that support the biological activity of the product
  • Orexin System: The Key for a Healthy Life.

    Chieffi et al (2017) Front Physiol 31;8 : 357
  • The sleep-modulating peptide orexin-B protects midbrain dopamine neurons from degeneration, alone or in cooperation with nicotine.

    Guerreiro et al (2015) Mol Phamacol. 87(3) : 525-32
  • Orexin/hypocretin: a neuropeptide at the interface of sleep, energy homeostasis, and reward system.

    Tsujino et al (2009) Pharmacol Rev 61(2) : 162-76

3 Item(s)