Ouabain

(HB1140)

Product overview

  • Name
    Ouabain
  • Short description
    Selective Na+ / K+ ATPase inhibitor
  • Biological description
    Selective Na+ / K+ ATPase inhibitor. Thought to act as a proliferative agent; promotes cardiac and vascular myocyte cell growth. Shows positive inotropic, vasoconstrictive and hypertensive actions.
  • Alternative names
    g-strophanthin
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-1,5,11α,14,19-pentahydoxycard-20(22)-enolide
  • Molecular Weight
    584.66
  • Chemical structure
    Ouabain  [630-60-4]
  • Molecular Formula
    C29H44O12.8H2O
  • CAS Number
    630-60-4
  • PubChem identifier
    439501
  • SMILES
    C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@H]2C[C@H]([C@@]3([C@@H]4[C@@H](CC[C@@]3(C2)O)[C@]5(CC[C@@H]([C@]5(C[C@H]4O)C)C6=CC(=O)OC6)O)CO)O)O)O)O
  • InChi
    InChI=1S/C29H44O12/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31/h7,13,15-19,21-25,30-32,34-38H,3-6,8-12H2,1-2H3/t13-,15-,16+,17+,18+,19+,21+,22-,23+,24+,25-,26+,27-,28
  • InChiKey
    LPMXVESGRSUGHW-HBYQJFLCSA-N
  • MDL number
    MFCD00149240
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    Soluble in water (10mM) and in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Ouabain

  • Effect of m-calpain in PKCalpha-mediated proliferation of pulmonary artery smooth muscle cells by low dose of ouabain.

    Shaikh S et al (2013) Indian J Biochem Biophys 50(5) : 419-27.
    PubMedID: 24772963
  • Increased constrictor tone induced by ouabain treatment in rats.

    Pulgar VM et al (2013) J Cardiovasc Pharmacol 62(2) : 174-83.
    PubMedID: 23615157
  • Different roles of the cardiac Na+/Ca2+-exchanger in ouabain-induced inotropy, cell signaling, and hypertrophy.

    Bai Y et al (2013) Am J Physiol Heart Circ Physiol 304(3) : H427-35.
    PubMedID: 23203972

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