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Product overview

  • Name
    PAC 1
  • Short description
    Procaspase-activating compound
  • Biological description
    Procaspase-activating compound. Chelates inhibitory zinc ions and activates procaspase-3 to caspase-3 (EC50 = 0.22 µM). Activates procaspase-7 (EC50 = 4.5 µM). No effect at low pH as procaspase autoactivates. Causes Ero1α-dependent calcium leakage from the endoplasmic reticulum to mitochondria. Shows apoptotic and anti-cancer actions.
  • Biological action
  • Purity
  • Citations


  • Chemical name
    4-(Phenylmethyl)-1-piperazineacetic acid [[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide
  • Molecular Weight
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for PAC 1

  • Procaspase-3 activation as an anti-cancer strategy: structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3.

    Peterson QP et al (2009) J Med Chem 52(18) : 5721-31.
    PubMedID: 19708658
  • Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy.

    Putt KS et al (2006) Nat Chem Biol 2(10) : 543-50.
    PubMedID: 16936720
  • ERO1α-dependent endoplasmic reticulum-mitochondrial calcium flux contributes to ER stress and mitochondrial permeabilization by procaspase-activating compound-1 (PAC-1).

    Seervi M et al (2013) Cell Death Dis 4 : e968.
    PubMedID: 24357799
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