Paroxetine hydrochloride

(HB0478)

Product overview

  • Name
    Paroxetine hydrochloride
  • Short description
    Potent, selective serotonin reuptake inhibitor. Selective GRK2 inhibitor.
  • Biological description
    Potent and selective serotonin (5-HT) reuptake inhibitor (Ki = 0.05 nM). Binds to the serotonin transporter (SERT). Also inhibits Norepinephrine transporter (NET) and increases NET and SERT expression. Additionally acts as a selective G-protein-receptor-kinase2 (GRK2) inhibitor, showing >50-fold selectivity over other GRKs. Shows antidepressant and anxiolytic actions.
  • Alternative names
    Paxil
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    (3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine;hydrochloride
  • Molecular Weight
    365.82
  • Chemical structure
    Paroxetine HCl  [78246-49-8]
  • Molecular Formula
    C19H21ClFNO3
  • CAS Number
    78246-49-8
  • PubChem identifier
    62878
  • SMILES
    C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.Cl
  • InChi
    InChI=1S/C19H20FNO3.ClH/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;/h1-6,9,14,17,21H,7-8,10-12H2;1H/t14-,17-;/m0./s1
  • InChiKey
    GELRVIPPMNMYGS-RVXRQPKJSA-N
  • MDL number
    MFCD03658863

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (100 mM)

References for Paroxetine hydrochloride

  • Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.

    Owens MJ et al (1997) J Pharmacol Exp Ther 283(3) : 1305-22.
    PubMedID: 9400006
  • Antidepressive effect of paroxetine in a rat model: upregulating expression of serotonin and norepinephrine transporter.

    Qiu HM et al (2013) Neuroreport 24(10) : 520-5.
    PubMedID: 23636256
  • Neuropharmacology of paroxetine.

    Nemeroff CB et al (2003) Psychopharmacol Bull 37 Suppl 1 : 8-18.
    PubMedID: 14566196

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