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Data

Product overview

  • Name
    Paxilline
  • Short description
    Potent, reversible, selective KCa channel inhibitor. Also SERCA inhibitor.
  • Biological description
    Potent, reversible and selective KCa channel inhibitor (Ki = 1.9 nM at α-subunit). Also sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor (IC50 = 5-50 µM). Indole alkaloid mycotoxin from Penicillium paxilli. Displays anticonvulsant properties.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    (2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a, 7,12,12b,12c,13,14,14a-Decahydro-4b-hydroxy-2-(1-h ydroxy-1-methylethyl)-12b,12c-dimethyl-2H-pyrano[2 '',3'':5',6']benz[1',2':6,7]indeno[1,2-b]indol-3(4bH)-one
  • Molecular Weight
    435.56
  • Chemical structure
    Paxilline  [57186-25-1]
  • Molecular Formula
    C27H33NO4
  • CAS Number
    57186-25-1

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Paxilline

  • Glycine311, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix.

    Zhou Y et al (2010) J Gen Physiol 135(5) : 481-94.
    PubMedID: 20421373
  • The mechanism of inhibition of the sarco/endoplasmic reticulum Ca2+ ATPase by paxilline.

    Bilmen JG et al (2002) Arch Biochem Biophys 406(1) : 55-64.
    PubMedID: 12234490
  • Anticonvulsant effects of the BK-channel antagonist paxilline.

    Sheehan JJ et al (2009) Epilepsia 50(4) : 711-20.
    PubMedID: 19054419
  • Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel.

    Sanchez M et al (1996) Neuropharmacology 35(7) : 963-8.
    PubMedID: 8938726
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