PCI 34051

(HB1393)

Product overview

  • Name
    PCI 34051
  • Short description
    Potent, selective HDAC8 inhibitor
  • Biological description
    Potent and selective histone deacetylase 8 (HDAC8) inhibitor (IC50 = 10 nM). Shows >200-fold selectivity over other HDAC isoforms (IC50 values are 2.9, 4, 13, >50 and >50 µM for HDAC6, 1, 10, 2 and 3 respectively). Shows apoptotic and anti-cancer actions.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    N-Hydroxy-1-[(4-methoxyphenyl)methy l]-1H-indole-6-carboxamide
  • Molecular Weight
    296.32
  • Chemical structure
    PCI 34051  [950762-95-5]
  • Molecular Formula
    C17H16N2O3
  • CAS Number
    950762-95-5

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in NaOH(aq) (20mM, 1eq. NaOH) or DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for PCI 34051

  • A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas.

    Balasubramanian S et al (2008) Leukemia 22(5) : 1026-34.
    PubMedID: 18256683
  • HDAC8-mediated epigenetic reprogramming plays a key role in resistance to anthrax lethal toxin-induced pyroptosis in macrophages.

    Ha SD et al (2014) J Immunol 193(3) : 1333-43.
    PubMedID: 24973453
  • Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain.

    Wang C et al (2013) Am J Nucl Med Mol Imaging 4(1) : 29-38.
    PubMedID: 24380043

Reviews & Product Guides