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Product overview

  • Name
    PD 173074
  • Short description
    FGFR1/ FGFR3 inhibitor. Inhibits oligodendrocyte progenitor proliferation and differentiation.
  • Biological description
    FGFR1/ FGFR3 inhibitor (IC50 values are 22 and 5 nM respectively). Inhibits angiogenesis. Also inhibits oligodendrocyte progenitor proliferation and differentiation.
  • Biological action
  • Purity
  • Citations


  • Chemical name
    N-[2-[[4-(Diethylamino)butyl]amino] -6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-y l]-N'-(1,1-dimethylethyl)urea
  • Molecular Weight
  • Chemical structure
    PD 173074 |  [219580-11-7]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for PD 173074

  • 1-tert-butyl-3-[6-(3,5-dimethoxy-phenyl)-2-(4-diethylamino-butylamino)-pyrido[2,3-d]pyrimidin-7-yl]-urea (PD173074), a selective tyrosine kinase inhibitor of fibroblast growth factor receptor-3 (FGFR3), inhibits cell proliferation of bladder cancer carryi

    Miyake et al (2010) J Pharmacol Exp Ther 332(3) : 795-802
    PubMedID: 19955487
  • The FGFR1 inhibitor PD 173074 selectively and potently antagonizes FGF-2 neurotrophic and neurotropic effects.

    Skaper et al (2000) J Neurochem 75(4) : 1520-7
    PubMedID: 10987832
  • The FGFR1 inhibitor PD173074 induces mesenchymal-epithelial transition through the transcription factor AP-1.

    Nguyen et al (2013) Br J Cancer 109(8) : 2248-58
    PubMedID: 24045665
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