FGFR1/ FGFR3 inhibitor (IC50 values are 22 and 5 nM respectively). Inhibits angiogenesis. Also inhibits oligodendrocyte progenitor proliferation and differentiation.
Solubility & Handling
Storage instructions
+4°C
Solubility overview
Soluble in DMSO (100mM) or ethanol (100mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
1-tert-butyl-3-[6-(3,5-dimethoxy-phenyl)-2-(4-diethylamino-butylamino)-pyrido[2,3-d]pyrimidin-7-yl]-urea (PD173074), a selective tyrosine kinase inhibitor of fibroblast growth factor receptor-3 (FGFR3), inhibits cell proliferation of bladder cancer carryi
Miyake et al (2010) J Pharmacol Exp Ther 332(3) : 795-802