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Product overview

  • Name
    PD 98059
  • Short description
    Selective MEK1/MAP2K inhibitor. Enhances ESC self-renewal.
  • Biological description
    Selective MEK1/MAP2K inhibitor (IC50 values are 2 and 50 µM at MEK1 and MEK2 respectively). Binds to inactivated MEK to prevent its phosphorylation by MEK kinase or c-Raf. Inhibits cell growth and proliferation and induces modest apoptosis. Also enhances embryonic stem cell self-renewal. Active in vivo .
  • Biological action
  • Purity
  • Citations



  • Chemical name
  • Molecular Weight
  • Chemical structure
    PD 98059
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChi
  • InChiKey
  • MDL number

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (25mM) and in ethanol (5mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for PD 98059

  • PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo.

    Alessi DR et al (1995) J Biol Chem 270(46) : 27489-94.
    PubMedID: 7499206
  • A synthetic inhibitor of the mitogen-activated protein kinase cascade.

    Dudley DT et al (1995) Proc Natl Acad Sci U S A 92(17) : 7686-9.
    PubMedID: 7644477
  • U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells.

    Hotokezaka H et al (2002) J Biol Chem 277(49) : 47366-72.
    PubMedID: 12237315
  • Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor.

    Pang L et al (1995) J Biol Chem 270(23) : 13585-8.
    PubMedID: 7775407
  • Pre-LTP requires extracellular signal-regulated kinase in the ACC.

    Yamanaka et al (2016) Mol Pain 12 : 1-12
    PubMedID: 27178245
Our products in action
The following papers have cited the use of PD 98059 (HB2244) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • Pre-LTP requires extracellular signal-regulated kinase in the ACC.

    Yamanaka et al (2016) Mol Pain 12 : 1-12
    PubMedID: 27178245
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