Penitrem A

(HB1057)

Product overview

  • Name
    Penitrem A
  • Short description
    Potent, selective KCa1.1 channel blocker
  • Biological description
    Potent and selective KCa1.1 channel blocker (IC50 values are 6.4 and 64.4 nM for α-subunit and β1 subunits respectively). Displays little or no activity at CaCC, Kv1.5 and KATP channels. Neurotoxin produced by Penicillium genus. Displays enhancing smooth muscle contracting and tremorgenic properties.
  • Biological action
    Blocker
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol
  • Molecular Weight
    634.2
  • Chemical structure
    Penitrem A  [12627-35-9]
  • Molecular Formula
    C37H44ClNO6
  • CAS Number
    12627-35-9

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in DMSO (10mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Penitrem A

  • Penitrem A as a tool for understanding the role of large conductance Ca(2+)/voltage-sensitive K(+) channels in vascular function.

    Asano S et al (2012) J Pharmacol Exp Ther 342(2) : 453-60.
    PubMedID: 22580348
  • Neurotoxicity of Penicillium crustosum secondary metabolites: tremorgenic activity of orally administered penitrem A and thomitrem A and E in mice.

    Moldes-Anaya A et al (2012) Toxicon 60(8) : 1428-35.
    PubMedID: 23085423
  • In vitro and in vivo hepatic metabolism of the fungal neurotoxin penitrem A.

    Moldes-Anaya A et al (2009) Drug Chem Toxicol 32(1) : 26-37.
    PubMedID: 19514936

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