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Penitrem A


Product overview

  • Name
    Penitrem A
  • Short description
    Potent, selective KCa1.1 channel blocker
  • Biological description
    Potent and selective KCa1.1 channel blocker (IC50 values are 6.4 and 64.4 nM for α-subunit and β1 subunits respectively). Displays little or no activity at CaCC, Kv1.5 and KATP channels. Neurotoxin produced by Penicillium genus. Displays enhancing smooth muscle contracting and tremorgenic properties.
  • Biological action
  • Purity
  • Citations


  • Chemical name
  • Molecular Weight
  • Chemical structure
    Penitrem A  [12627-35-9]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChiKey

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (10mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Penitrem A

  • Penitrem A as a tool for understanding the role of large conductance Ca(2+)/voltage-sensitive K(+) channels in vascular function.

    Asano S et al (2012) J Pharmacol Exp Ther 342(2) : 453-60.
    PubMedID: 22580348
  • Neurotoxicity of Penicillium crustosum secondary metabolites: tremorgenic activity of orally administered penitrem A and thomitrem A and E in mice.

    Moldes-Anaya A et al (2012) Toxicon 60(8) : 1428-35.
    PubMedID: 23085423
  • In vitro and in vivo hepatic metabolism of the fungal neurotoxin penitrem A.

    Moldes-Anaya A et al (2009) Drug Chem Toxicol 32(1) : 26-37.
    PubMedID: 19514936
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