Product overview

  • Name
    PEP 005
  • Short description
    Broad spectrum PKC agonist
  • Biological description
    Broad spectrum protein kinase C (PKC) agonist. Also inhibits AKT pathway. Displays pro-apoptotic, anti-proliferative, pro-inflammatory and anti-cancer properties.
  • Alternative names
    Ingenol 3-angelate
  • Biological action
    Agonist
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    (2Z)-2-Methyl-2-butenoic acid (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2 ,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydro xymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-metha nocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester
  • Molecular Weight
    430.53
  • Chemical structure
    PEP 005  [75567-37-2]
  • Molecular Formula
    C25H34O6
  • CAS Number
    75567-37-2

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in DMSO (2mM)

References for PEP 005

  • Kinetics of ERK1/2 activation determine sensitivity of acute myeloid leukaemia cells to the induction of apoptosis by the novel small molecule ingenol 3-angelate (PEP005).

    Hampson P et al (2010) Apoptosis 15(8) : 946-55.
    PubMedID: 20467815
  • The protein kinase C agonist PEP005 (ingenol 3-angelate) in the treatment of human cancer: a balance between efficacy and toxicity.

    Ersvaer E et al (2010) Toxins (Basel) 2(1) : 174-94.
    PubMedID: 22069553
  • Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells.

    Serova M et al (2008) Mol Cancer Ther 7(4) : 915-22.
    PubMedID: 18413805
  • Antiproliferative activity of PEP005, a novel ingenol angelate that modulates PKC functions, alone and in combination with cytotoxic agents in human colon cancer cells.

    Benhadji KA et al (2008) Br J Cancer 99(11) : 1808-15.
    PubMedID: 19034280

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