Product overview

Name PEP 005
Alternative names Ingenol 3-angelate
Purity >98%
Description Broad spectrum PKC agonist
Write Your Own Review
You're reviewing:PEP 005
Rate this item:

Biological Data

Biological description Broad spectrum protein kinase C (PKC) agonist. Also inhibits AKT pathway. Displays pro-apoptotic, anti-proliferative, pro-inflammatory and anti-cancer properties.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (2mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >98%
Chemical name (2Z)-2-Methyl-2-butenoic acid (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2 ,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydro xymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-metha nocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester
Molecular Weight 430.53
Chemical structure PEP 005  [75567-37-2] Chemical Structure
Molecular Formula C25H34O6
CAS Number 75567-37-2
PubChem identifier 6918670
SMILES CC([C@@H]2OC(/C(C)=C\C)=O)=C[C@@]1([C@H](C)C4)[C@]2(O)[C@H](O)C(CO)=C[C@]([C@@]3([H])[C@]4([H])C(C)3C)([H])C1=O
InChiKey VDJHFHXMUKFKET-WDUFCVPESA-N

References for PEP 005

References are publications that support the biological activity of the product
  • Kinetics of ERK1/2 activation determine sensitivity of acute myeloid leukaemia cells to the induction of apoptosis by the novel small molecule ingenol 3-angelate (PEP005).

    Hampson P et al (2010) Apoptosis 15(8) : 946-55.
  • The protein kinase C agonist PEP005 (ingenol 3-angelate) in the treatment of human cancer: a balance between efficacy and toxicity.

    Ersvaer E et al (2010) Toxins (Basel) 2(1) : 174-94.
  • Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells.

    Serova M et al (2008) Mol Cancer Ther 7(4) : 915-22.
  • Antiproliferative activity of PEP005, a novel ingenol angelate that modulates PKC functions, alone and in combination with cytotoxic agents in human colon cancer cells.

    Benhadji KA et al (2008) Br J Cancer 99(11) : 1808-15.

4 Item(s)