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Perlapine hydrochloride (water soluble)

(HB6126)
Data

Product overview

  • Name
    Perlapine hydrochloride (water soluble)
  • Short description
    Novel, potent and selective hM3Dq DREADD receptor agonist. Water soluble.
  • Biological description

    Perlapine hydrochloride is a water soluble version of perlapine which is a novel, potent and selective, non-CNO (Clozapine N Oxide) hM3Dq DREADD receptor agonist (EC50 = 2.8 nM). Perlapine also activates the inhibitory hM2Di and hM4Di Gi-DREADDs.


    Perlapine shows >10,000-fold selectivity for hM3Dq over hM3 muscarinic receptor.

    Unlike CNO, perlapine is especially suited for translational studies. Perlapine also acts as a sleep inducing, hypnotic agent.


    Clozapine N-oxide (CNO) (water soluble), Compound 21, Salvinorin B (SalB) and perlapine freebase  are also available.

  • Alternative names
    NSC291840 hydrochloride
  • Biological action
    Activator
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    6-(4-Methyl-1-piperazinyl)-11H-dibenz[b,e]azepine dihydrochloride
  • Molecular Weight
    360.3
  • Chemical structure
    Perlapine hydrochloride
  • Molecular Formula
    C19H21N3.2HCl
  • SMILES
    CN1CCN(CC1)C2=NC3=CC=CC=C3CC4=CC=CC=C42.Cl.Cl
  • Source
    Synthetic
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (100 mM)
  • Handling
    Hydroscopic solid, contact with air may cause material to become sticky. Product performance should not be affected but we recommend storing the material in a sealed jar.
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

References for Perlapine hydrochloride (water soluble)

  • The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs.

    Chen et al (2015) ACS Chem Neurosci 6(3) : 476-84
    PubMedID: 25587888
  • 6-(4-Methyl-1-piperazinyl)morphanthridine (Perlapine), a new tricyclic compound with sedative and sleep-promoting properties. A pharmacological study.

    Stille et al (1973) Psychopharmacologia 24(4) : 325-37
    PubMedID: 4695567
  • DREADDs for Neuroscientists.

    Roth Bl (2016) Neuron 89(4) : 683-94
    PubMedID: 26889809
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