Product overview

  • Name
    Perlapine
  • Short description
    Novel, potent and selective hM3Dq DREADD receptor agonist
  • Biological description

    Perlapine is a novel, potent and selective, non-CNO (Clozapine N Oxide) hM3Dq DREADD receptor agonist (EC50 = 2.8 nM) which also activates the inhibitory hM2Di and hM4Di Gi-DREADDs.


    Perlapine shows >10,000-fold selectivity for hM3Dq over hM3 muscarinic receptor.

    Unlike CNO, perlapine is especially suited for translational studies.

    Also acts as a sleep inducing, hypnotic agent.


    Water soluble Clozapine N-oxide (CNO) also available.

  • Alternative names
    NSC291840
  • Biological action
    Activator
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    6-(4-Methyl-1-piperazinyl)-11H-dibenz[b,e]azepine
  • Molecular Weight
    291.4
  • Chemical structure
    Perlapine [1977-11-3]
  • Molecular Formula
    C19H21N3
  • CAS Number
    1977-11-3
  • PubChem identifier
    16106
  • SMILES
    CN1CCN(CC1)C2=NC3=CC=CC=C3CC4=CC=CC=C42
  • Source
    Synthetic
  • InChi
    InChI=1S/C19H21N3/c1-21-10-12-22(13-11-21)19-17-8-4-2-6-15(17)14-16-7-3-5-9-18(16)20-19/h2-9H,10-14H2,1H3
  • InChiKey
    PWRPUAKXMQAFCJ-UHFFFAOYSA-N
  • MDL number
    MFCD00242700
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (50 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Perlapine

  • The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs.

    Chen et al (2015) ACS Chem Neurosci 6(3) : 476-84
    PubMedID: 25587888
  • 6-(4-Methyl-1-piperazinyl)morphanthridine (Perlapine), a new tricyclic compound with sedative and sleep-promoting properties. A pharmacological study.

    Stille et al (1973) Psychopharmacologia 24(4) : 325-37
    PubMedID: 4695567
  • DREADDs for Neuroscientists.

    Roth Bl (2016) Neuron 89(4) : 683-94
    PubMedID: 26889809