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Pertussis Toxin


Product overview

  • Name
    Pertussis Toxin
  • Short description
    Catalyzes ADP-ribosylation of the G proteins Gαi, Gαo and Gαt
  • Biological description

    Toxin produced by Bordetella pertussis . Catalyzes ADP-ribosylation of the α subunits of the heterotrimeric Gi/o proteins; Gαi, Gαo and Gαt . Blocks receptor coupling and activation by preventing G protein heterotrimers from interacting with receptors.


    This product is not activated. Cells will activate pertussis toxin in an intact system however activation is required in a cell free system. Incubation with high concentrations of dithiothreitol (DTT) can achieve activation, see Kaslow, et al. (1987) for suggested conditions.


  • Alternative names
    PTX | PT | Islet-activating protein | Holotoxin
  • Biological action
  • Purity
  • Citations


  • CAS Number
  • Source
    B. pertussis
  • Appearance
  • Formulation
    Contains 0.05M sodium phosphate and 0.5M sodium chloride at pH 7.2.

Storing and Using Your Product

  • Storage instructions
    +4°C for lyophilised or resuspended (do not freeze).
  • Handling

    Use solutions within 1 month, long term storage is not recommended.

    Before use the suspension should be gently mixed (not vortexed) to make the suspension uniform. Do not sterile filter.

    Pertussis toxin can be inactivated by boiling for 30mins

  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Pertussis Toxin

  • Subunit structure of islet-activating protein, pertussis toxin, in conformity with the A-B model.

    Tamura et al (1982) Biochemistry 21(22) : 5516-22.
    PubMedID: 6293544
  • Structure-activity analysis of the activation of pertussis toxin.

    Kaslow et al (1987) Biochemistry 26(1) : 123-7
    PubMedID: 3030399
  • G(i/o) protein-dependent and -independent actions of Pertussis Toxin (PTX).

    Mangmool and Kurose (2011) Toxins (Basel) 3(7) : 884-99
    PubMedID: 22069745
Our products in action
The following papers have cited the use of Pertussis Toxin (HB4729) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • Cannabichromene is a cannabinoid CB2 receptor agonist

    Udoh et al (2018) bioRxiv doi: :
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