PF 03814735

(HB1441)

Product overview

  • Name
    PF 03814735
  • Short description
    Potent Aurora kinase inhibitor
  • Biological description
    Potent Aurora kinase inhibitor. Reversibly inhibits Aurora B and -A (IC50 values are 0.8 and 5 nM respectively). Shows antiproliferative and anti-cancer actions.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    N-[2-[(1S,4R)-6-[[4-(Cyclobutylamin o)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1,2,3, 4-tetrahydronaphthalen-1,4-imin-9-yl]-2-oxoethyl]- acetamide
  • Molecular Weight
    474.48
  • Chemical structure
    PF 03814735  [942487-16-3]
  • Molecular Formula
    C23H25F3N6O2
  • CAS Number
    942487-16-3

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (20mM)

References for PF 03814735

  • PF-03814735, an orally bioavailable small molecule aurora kinase inhibitor for cancer therapy.

    Jani JP et al (2010) Mol Cancer Ther 9(4) : 883-94.
    PubMedID: 20354118
  • An integrated genomic approach to identify predictive biomarkers of response to the aurora kinase inhibitor PF-03814735.

    Hook KE et al (2012) Mol Cancer Ther 11(3) : 710-9.
    PubMedID: 22222631

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