PF 3716556

(HB1123)

Product overview

  • Name
    PF 3716556
  • Short description
    Potent, selective acid pump antagonist
  • Biological description
    Potent and selective acid pump antagonist (pIC50 values are 6.03, 6.04 and 6.01 for Porcine, Canine and Human recombinant ion leaky assay respectively). Competitively inhibits H+, K+ -ATPase but exhibits no activity against Na+, K+ -ATPase. Displays greater potency in acidic conditions. Also inhibits gastric acid secretion in dogs.
  • Biological action
    Antagonist
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    8-[[(4R)-3,4-Dihydro-5-methyl-2H-1- benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethyl-imidazo[1,2-a]pyridine-6-carboxamide
  • Molecular Weight
    394.47
  • Chemical structure
    PF 3716556  [928774-43-0]
  • Molecular Formula
    C22H26N4O3
  • CAS Number
    928774-43-0

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in DMSO (100mM)

References for PF 3716556

  • N-(2-hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide (PF-03716556), a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease.

    Mori H et al (2009) J Pharmacol Exp Ther 328(2) : 671-9.
    PubMedID: 18981288

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