Product overview

Name PF 3716556
Purity >98%
Description Potent, selective acid pump antagonist
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Biological Data

Biological description Potent and selective acid pump antagonist (pIC50 values are 6.03, 6.04 and 6.01 for Porcine, Canine and Human recombinant ion leaky assay respectively). Competitively inhibits H+, K+ -ATPase but exhibits no activity against Na+, K+ -ATPase. Displays greater potency in acidic conditions. Also inhibits gastric acid secretion in dogs.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >98%
Chemical name 8-[[(4R)-3,4-Dihydro-5-methyl-2H-1- benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethyl-imidazo[1,2-a]pyridine-6-carboxamide
Molecular Weight 394.47
Chemical structure PF 3716556  [928774-43-0] Chemical Structure
Molecular Formula C22H26N4O3
CAS Number 928774-43-0
PubChem identifier 25134521
SMILES OCCN(C)C(C2=CN1C(C(N[C@H]4C3=C(C)C=CC=C3OCC4)=C2)=NC(C)=C1)=O
InChiKey YBHKBMJREUZHOV-QGZVFWFLSA-N

References for PF 3716556

References are publications that support the biological activity of the product
  • N-(2-hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide (PF-03716556), a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease.

    Mori H et al (2009) J Pharmacol Exp Ther 328(2) : 671-9.

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