Philanthotoxin-7,4

(HB0499)

Product overview

  • Name
    Philanthotoxin-7,4
  • Short description
    AMPA receptor antagonist
  • Biological description
    AMPA receptor antagonist. Non-selective inhibitor of homomeric GluA1 and GluA3 subunit-containing receptors and heteromeric receptor GluA1/2 subunits (IC50 = 22 µM).
  • Biological action
    Antagonist
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    (S)-N-[7-[(4-Aminobutyl)amino]heptyl]-4-hydroxy-α-[(1-oxobutyl)amino]benzenepropanamide dihydrochloride
  • Molecular Weight
    507.54
  • Chemical structure
    Philanthotoxin-7,4  [1227301-51-0]
  • Molecular Formula
    C24H42N4O3.2HCl
  • CAS Number
    1227301-51-0
  • PubChem identifier
    46213501
  • SMILES
    Cl.Cl.Oc1ccc(C[C@H](NC(=O)CCC)C(=O)NCCCCCCCNCCCCN)cc1

Storing and Using Your Product

  • Storage instructions
    room temperature (desiccate)
  • Solubility overview
    soluble in water (100mM) or DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Philanthotoxin-7,4

  • A subtype-selective, use-dependent inhibitor of native AMPA receptors.

    Nilsen A et al (2007) J Am Chem Soc 129(16) : 4902-3.
    PubMedID: 17391037
  • Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors.

    Poulsen MH et al (2014) Mol Pharmacol 85(2) : 261-8.
    PubMedID: 24220009
  • Solid-phase synthesis of polyamine toxin analogues: potent and selective antagonists of Ca2+-permeable AMPA receptors.

    Kromann H et al (2002) J Med Chem 45(26) : 5745-54.
    PubMedID: 12477358