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Biological Data
| Biological description | Protein kinase C (PKC) inhibitor. PGF2a receptor antagonist (IC50 = 16 µM). Inhibits GLUT2 glucose transport. Shows apoptotic, antitumor, antioxidant and immunomodulatory actions. |
Solubility & Handling
| Solubility overview | Soluble in ethanol or methanol |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical structure | ![Phloretin [60-82-2] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Phloretin [60-82-2]") |
| Molecular Formula | C15H14O5 |
| SMILES | OC1=CC=C(CCC(=O)C2=C(O)C=C(O)C=C2O)C=C1 |
References for Phloretin
References are publications that support the biological activity of the product
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Immunomodulation of phloretin by impairing dendritic cell activation and function.
Lin CC et al (2014) Food Funct 5(5) : 997-1006. -
In vitro and in vivo study of phloretin-induced apoptosis in human liver cancer cells involving inhibition of type II glucose transporter.
Wu CH et al (2009) Int J Cancer 124(9) : 2210-9. -
Phloretin-induced apoptosis in B16 melanoma 4A5 cells and HL60 human leukemia cells.
Kobori M et al (1999) Biosci Biotechnol Biochem 63(4) : 719-25. -
Phloretin as an antagonist of prostaglandin F2 alpha receptor in cultured rat astrocytes.
Kitanaka J et al (1993) J Neurochem 60(2) : 704-8.
![Phloretin [60-82-2] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0500.png "Phloretin [60-82-2]")
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