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Phorbol 12-myristate 13-acetate (PMA)


Product overview

  • Name
    Phorbol 12-myristate 13-acetate (PMA)
  • Short description
    PKC activator
  • Biological description

    Phorbol 12-myristate 13-acetate (PMA) is a protein kinase C (PKC) activator which associates to the C1 domain. It is structurally analogous to diacylglycerol.

    PMA is a potent tumor promoter.

    PMA induces ERK1/2 activation and is frequently used with ionomycin to stimulate intracellular cytokine production in T-cells.

    PMA also facilitates long term potentiation in hippocampal neurons via δ and ε PKC binding sites.

    Additionally, PMA potentiates exocytosis and modulates vesicle fusion kinetics.

  • Alternative names
    PMA; TPA
  • Biological action
  • Purity
  • Customer comments

    Shipping at RT but it works properly. cheap and quick delivery. Verified customer, Seoul National University

  • Citations



  • Chemical name
    (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(Acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a ,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl tetradecanoate
  • Molecular Weight
  • Chemical structure
    Phorbol 12-myristate 13-acetate  [16561-29-8]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChi
  • InChiKey
  • MDL number

Storing and Using Your Product

  • Storage instructions
    -20°C (protect from light)
  • Solubility overview
    Soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Phorbol 12-myristate 13-acetate (PMA)

  • Phorbol 12-myristate 13-acetate inhibits P-glycoprotein-mediated efflux of digoxin in MDCKII-MDR1 and Caco-2 cell monolayer models.

    Li YH et al (2014) Acta Pharmacol Sin 35(2) : 283-91.
    PubMedID: 24362330
  • Phorbol ester phorbol-12-myristate-13-acetate promotes anchorage-independent growth and survival of melanomas through MEK-independent activation of ERK1/2.

    Jørgensen K et al (2005) Biochem Biophys Res Commun 329(1) : 266-74.
    PubMedID: 15721302
  • Involvement of PKC alpha in PMA-induced facilitation of exocytosis and vesicle fusion in PC12 cells.

    Xue R et al (2009) Biochem Biophys Res Commun 380(2) : 371-6.
    PubMedID: 19250646
  • Phorbol 12-Myristate 13-Acetate Enhances Long-Term Potentiation in the Hippocampus through Activation of Protein Kinase Cδ and ε.

    Kim EC et al (2013) Korean J Physiol Pharmacol 17(1) : 51-6.
    PubMedID: 23440225
Our products in action
The following papers have cited the use of Phorbol 12-myristate 13-acetate (PMA) (HB0502) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • mGluR-LTD at Excitatory and Inhibitory Synapses in the Lateral Habenula Tunes Neuronal Output.

    Valentinova and Mameli(2016) Cell Rep 16(9) : 2298-307
    PubMedID: 27545888
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Reviews & Product Guides


  • Verified customer, Seoul National University

    Shipping at RT but it works properly. cheap and quick delivery.