Phorbol 12-myristate 13-acetate (PMA)

(HB0502)

Product overview

  • Name
    Phorbol 12-myristate 13-acetate (PMA)
  • Short description
    PKC activator
  • Biological description

    Protein kinase C (PKC) activator which associates to C1 domain. Structurally analogous to diacylglycerol. Induces ERK1/2 activation.

    Frequently used with ionomycin to stimulate intracellular cytokine production in T-cells.

    Facilitates long term potentiation in hippocampal neurons via δ and ε PKC binding sites.

    Also potentiates exocytosis and modulates vesicle fusion kinetics.

    Displays tumor promoting properties.

  • Alternative names
    PMA; TPA
  • Biological action
    Activator
  • Purity
    >99%
  • Our products in action

Images

Properties

  • Chemical name
    (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(Acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a ,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl tetradecanoate
  • Molecular Weight
    616.83
  • Chemical structure
    Phorbol 12-myristate 13-acetate  [16561-29-8]
  • Molecular Formula
    C36H56O8
  • CAS Number
    16561-29-8
  • PubChem identifier
    27924
  • SMILES
    CCCCCCCCCCCCCC(=O)O[C@@H]1[C@H]([C@]2([C@@H](C=C(C[C@]3([C@H]2C=C(C3=O)C)O)CO)[C@H]4[C@@]1(C4(C)C)OC(=O)C)O)C
  • InChi
    InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1
  • InChiKey
    PHEDXBVPIONUQT-RGYGYFBISA-N
  • MDL number
    MFCD00036736

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    Soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Phorbol 12-myristate 13-acetate (PMA)

  • Phorbol 12-myristate 13-acetate inhibits P-glycoprotein-mediated efflux of digoxin in MDCKII-MDR1 and Caco-2 cell monolayer models.

    Li YH et al (2014) Acta Pharmacol Sin 35(2) : 283-91.
    PubMedID: 24362330
  • Phorbol ester phorbol-12-myristate-13-acetate promotes anchorage-independent growth and survival of melanomas through MEK-independent activation of ERK1/2.

    Jørgensen K et al (2005) Biochem Biophys Res Commun 329(1) : 266-74.
    PubMedID: 15721302
  • Involvement of PKC alpha in PMA-induced facilitation of exocytosis and vesicle fusion in PC12 cells.

    Xue R et al (2009) Biochem Biophys Res Commun 380(2) : 371-6.
    PubMedID: 19250646
  • Phorbol 12-Myristate 13-Acetate Enhances Long-Term Potentiation in the Hippocampus through Activation of Protein Kinase Cδ and ε.

    Kim EC et al (2013) Korean J Physiol Pharmacol 17(1) : 51-6.
    PubMedID: 23440225
The following papers have cited the use of Phorbol 12-myristate 13-acetate (PMA) (HB0502) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • mGluR-LTD at Excitatory and Inhibitory Synapses in the Lateral Habenula Tunes Neuronal Output.

    Valentinova and Mameli(2016) Cell Rep 16(9) : 2298-307
    PubMedID: 27545888

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