PHT 427

(HB1251)

Product overview

  • Name
    PHT 427
  • Short description
    Akt / PDPK1 inhibitor
  • Biological description
    Akt (PKB) and phosphatidylinositol 3-kinase (PDPK1) inhibitor (Ki values are 2.7 and 5.2 µM respectively). Binds at the pleckstrin homology (PH) domain of AKT and PDPK1. Shows anti-tumor and apoptotic actions.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    4-Dodecyl-N-1,3,4-thiadiazol-2-yl-benzenesulfonamide
  • Molecular Weight
    409.61
  • Chemical structure
    PHT 427  [1191951-57-1]
  • Molecular Formula
    C20H31N3O2S2
  • CAS Number
    1191951-57-1

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for PHT 427

  • In vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT.

    Moses SA et al (2009) Cancer Res 69(12) : 5073-81.
    PubMedID: 19491272
  • Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.

    Meuillet EJ et al (2010) Mol Cancer Ther 9(3) : 706-17.
    PubMedID: 20197390

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