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Pifithrin-μ

(HB3025)
Data

Product overview

  • Name
    Pifithrin-μ
  • Short description
    p53 inhibitor. Supresses eSC self renewal.
  • Biological description
    p53-mitochondrial binding inhibitor which inhibits p53-mediated apoptosis. Also a HSP70 inhibitor. Supresses embroynic stem cell (eSC) self renewal.
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    2-Phenylethynesulfonamide
  • Molecular Weight
    181.21
  • Chemical structure
    Pifithrin-µ |  [64984-31-2]
  • Molecular Formula
    C8H7NO2S
  • CAS Number
    64984-31-2

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Pifithrin-μ

  • The HSP70 and autophagy inhibitor pifithrin-μ enhances the antitumor effects of TRAIL on human pancreatic cancer.

    Monma et al (2013) Mol Cancer Ther 12(4) : 341-51
    PubMedID: 23371857
  • Linking the p53 tumour suppressor pathway to somatic cell reprogramming.

    Kawamura et al (2009) Nature 460(7259) : 1140-4
    PubMedID: 19668186
  • Prevention of chemotherapy-induced peripheral neuropathy by the small-molecule inhibitor pifithrin-μ.

    Krukowski et al (2015) Pain 156(11) : 2184-92
    PubMedID: 26473292
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