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Biological Data
| Biological description | p53-mitochondrial binding inhibitor which inhibits p53-mediated apoptosis. Also a HSP70 inhibitor. Supresses embroynic stem cell (eSC) self renewal.
By silencing p53, it may also increase human somatic cells to induced pluripotent stem cells (iPSCs) reprogramming efficiency. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100mM) or ethanol (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 2-Phenylethynesulfonamide |
| Chemical structure | ![Pifithrin-µ | [64984-31-2] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Pifithrin-µ | [64984-31-2]") |
| Molecular Formula | C8H7NO2S |
| PubChem identifier | 327653 |
| SMILES | NS(=O)(=O)C#CC1=CC=CC=C1 |
| InChiKey | ZZUZYEMRHCMVTB-UHFFFAOYSA-N |
References for Pifithrin-μ
References are publications that support the biological activity of the product
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Prevention of chemotherapy-induced peripheral neuropathy by the small-molecule inhibitor pifithrin-μ.
Krukowski et al (2015) Pain 156(11) : 2184-92 -
The HSP70 and autophagy inhibitor pifithrin-μ enhances the antitumor effects of TRAIL on human pancreatic cancer.
Monma et al (2013) Mol Cancer Ther 12(4) : 341-51 -
Linking the p53 tumour suppressor pathway to somatic cell reprogramming.
Kawamura et al (2009) Nature 460(7259) : 1140-4
p53 inhibitor. Supresses eSC self renewal and may increase stem cell reprogramming efficiency.
![Pifithrin-µ | [64984-31-2] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb3025b.png "Pifithrin-µ | [64984-31-2]")
Understanding purity and quality - a guide for life scientists
