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Product overview

  • Name
    PK 11195
  • Short description
    Peripheral benzodiazepine receptor ligand
  • Biological description
    Peripheral benzodiazepine receptor ligand. Inhibits the constitutive androstane receptor (CAR; NR1I3). Shows actions against Alzheimer's disease. Shows anti-convulsive actions.
  • Biological action
  • Purity
  • Citations


  • Chemical name
  • Molecular Weight
  • Chemical structure
    PK 11195  [85532-75-8]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in ethanol (50mM) or DMSO (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for PK 11195

  • PK 11195 attenuates kainic acid-induced seizures and alterations in peripheral-type benzodiazepine receptor (PBR) protein components in the rat brain.

    Veenman L et al (2002) J Neurochem 80(5) : 917-27.
    PubMedID: 11948256
  • The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human constitutive androstane receptor.

    Li L et al (2008) Mol Pharmacol 74(2) : 443-53.
    PubMedID: 18492798
  • Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease.

    Barron AM et al (2013) J Neurosci 33(20) : 8891-7.
    PubMedID: 23678130
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