Product overview

  • Name
    PK 11195
  • Short description
    Peripheral benzodiazepine receptor ligand
  • Biological description
    Peripheral benzodiazepine receptor ligand. Inhibits the constitutive androstane receptor (CAR; NR1I3). Shows actions against Alzheimer's disease. Shows anti-convulsive actions.
  • Biological action
    Antagonist
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide
  • Molecular Weight
    352.86
  • Chemical structure
    PK 11195  [85532-75-8]
  • Molecular Formula
    C21H21ClN2O
  • CAS Number
    85532-75-8

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in ethanol (50mM) or DMSO (50mM)

References for PK 11195

  • PK 11195 attenuates kainic acid-induced seizures and alterations in peripheral-type benzodiazepine receptor (PBR) protein components in the rat brain.

    Veenman L et al (2002) J Neurochem 80(5) : 917-27.
    PubMedID: 11948256
  • The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human constitutive androstane receptor.

    Li L et al (2008) Mol Pharmacol 74(2) : 443-53.
    PubMedID: 18492798
  • Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease.

    Barron AM et al (2013) J Neurosci 33(20) : 8891-7.
    PubMedID: 23678130

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