Write Your Own Review
You're reviewing:PK 11195
Rate this item:

Images

PK 11195 product vial image | Hello Bio

Biological Data

Biological description Peripheral benzodiazepine receptor ligand. Inhibits the constitutive androstane receptor (CAR; NR1I3). Shows actions against Alzheimer's disease. Shows anti-convulsive actions.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in ethanol (50mM) or DMSO (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >98%
Chemical name 1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide
Molecular Weight 352.86
Chemical structure PK 11195  [85532-75-8] Chemical Structure
Molecular Formula C21H21ClN2O
CAS Number 85532-75-8
PubChem identifier 1345
SMILES CCC(C)N(C)C(=O)C1=NC(C2=CC=CC=C2Cl)=C2C=CC=CC2=C1
InChiKey RAVIZVQZGXBOQO-UHFFFAOYSA-N

References for PK 11195

References are publications that support the biological activity of the product
  • Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease.

    Barron AM et al (2013) J Neurosci 33(20) : 8891-7.
  • The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human constitutive androstane receptor.

    Li L et al (2008) Mol Pharmacol 74(2) : 443-53.
  • PK 11195 attenuates kainic acid-induced seizures and alterations in peripheral-type benzodiazepine receptor (PBR) protein components in the rat brain.

    Veenman L et al (2002) J Neurochem 80(5) : 917-27.

3 Item(s)