PKA inhibitor fragment (6-22) amide

(HB0508)

Product overview

  • Name
    PKA inhibitor fragment (6-22) amide
  • Short description
    Potent PKA inhibitor
  • Biological description
    Potent protein kinase A (PKA) inhibitor (Ki = 1.6 nM). Decreases long-term potentiation (LTP) at hippocampal synapses. Reverses morphine tolerance.
  • Biological action
    Inhibitor
  • Our products in action

Properties

  • Molecular Weight
    1868.08
  • Molecular Formula
    C80H130N28O24
  • CAS Number
    121932-06-7

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    soluble in acetonitrile
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for PKA inhibitor fragment (6-22) amide

  • Protein kinase inhibitor-(6-22)-amide peptide analogs with standard and nonstandard amino acid substitutions for phenylalanine 10. Inhibition of cAMP-dependent protein kinase.

    Glass DB et al (1989) J Biol Chem 264(24) : 14579-84.
    PubMedID: 2760075
  • Inhibition of the cAMP pathway decreases early long-term potentiation at CA1 hippocampal synapses.

    Otmakhova NA et al (2000) J Neurosci 20(12) : 4446-51.
    PubMedID: 10844013
  • Alterations in brain Protein Kinase A activity and reversal of morphine tolerance by two fragments of native Protein Kinase A inhibitor peptide (PKI).

    Dalton GD et al (2005) Neuropharmacology 48(5) : 648-57.
    PubMedID: 15814100

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