PKA inhibitor fragment (6-22) amide

(HB0508)
Technical documents: SDS Datasheet

Product overview

Name PKA inhibitor fragment (6-22) amide
Alternative names Protein kinase inhibitor-(6-22)-amide, PKI-(6-22)-amide
Description Potent PKA inhibitor
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Biological Data

Biological description Potent protein kinase A (PKA) inhibitor (Ki = 1.6 nM). Decreases long-term potentiation (LTP) at hippocampal synapses. Reverses morphine tolerance.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in acetonitrile
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Molecular Weight 1868.08
Molecular Formula C80H130N28O24
CAS Number 121932-06-7
PubChem identifier 16155227
SMILES [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O
InChiKey VAKHFAFLRUNHLQ-PEBJKXEYSA-N

References for PKA inhibitor fragment (6-22) amide

References are publications that support the biological activity of the product
  • Alterations in brain Protein Kinase A activity and reversal of morphine tolerance by two fragments of native Protein Kinase A inhibitor peptide (PKI).

    Dalton GD et al (2005) Neuropharmacology 48(5) : 648-57.
  • Inhibition of the cAMP pathway decreases early long-term potentiation at CA1 hippocampal synapses.

    Otmakhova NA et al (2000) J Neurosci 20(12) : 4446-51.
  • Protein kinase inhibitor-(6-22)-amide peptide analogs with standard and nonstandard amino acid substitutions for phenylalanine 10. Inhibition of cAMP-dependent protein kinase.

    Glass DB et al (1989) J Biol Chem 264(24) : 14579-84.

3 Item(s)