Product overview

Name PKA Inhibitor IV
Alternative names PKI (5-24)
Description Potent, selective PKA inhibitor
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Biological Data

Biological description Potent and selective protein kinase A (PKA) inhibitor (Ki = 2.8 nM).

Solubility & Handling

Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name L-threonyl-L-threonyl-L-tyrosyl-L-alanyl-L-a-aspartyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-serylglycyl-L-arginyl-L-threonylglycyl-larginyl-L-aspartic acid
Molecular Weight 2222.4
Molecular Formula C18H24N4O3S.2HCl
CAS Number 99534-03-9
SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)O)C(C)O)[C@@H](C)CC)C(C)O)C(=O)N[C@@H](Cc3[nH]cnc3)C(=O)N[C@@H](CC(O)=O)C(O)=O

References for PKA Inhibitor IV

References are publications that support the biological activity of the product
  • Sargaquinoic acid promotes neurite outgrowth via protein kinase A and MAP kinases-mediated signaling pathways in PC12D cells.

    Kamei Y et al (2003) Int J Dev Neurosci 21(5) : 255-62.
  • Ribosomal protein S6 phosphorylation and function during late gestation liver development in the rat.

    Boylan JM et al (2001) J Biol Chem 276(48) : 44457-63.

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