Product overview

  • Name
    PKC-412
  • Short description
    Broad spectrum protein kinase inhibitor
  • Biological description
    Broad spectrum protein kinase inhibitor. Inhibits PKC (isoforms α, β and γ), Syk, FLK-1, PKA, c-kit, Akt, FLT3, VEGFR1, VEGFR2, EGFR and c-src. Also selectively blocks TNF-α production. Displays antitumor, antiproliferative and pro-apoptotic properties.
  • Alternative names
    CGP 41251; Midostaurin; 4'-N-benzoylstaurosporine; PKC412
  • Biological action
    Inhibitor
  • Purity
    >96%
  • Our products in action

Properties

  • Chemical name
    Midostaurin; 4'-N-benzoylstaurosporine
  • Molecular Weight
    570.64
  • Chemical structure
    PKC-412  [120685-11-2]
  • Molecular Formula
    C35H30N4O4
  • CAS Number
    120685-11-2

Storing and Using Your Product

  • Solubility overview
    soluble in DMSO (15mg/ml) or MDC (10mg/ml)

References for PKC-412

  • PKC412--a protein kinase inhibitor with a broad therapeutic potential.

    Fabbro D et al (2000) Anticancer Drug Des 15(1) : 17-28.
    PubMedID: 10888033
  • Effects of the kinase inhibitor CGP41251 (PKC 412) on lymphocyte activation and TNF-alpha production.

    Si MS et al (2005) Int Immunopharmacol 5(7-8) : 1141-9.
    PubMedID: 15914319
  • The phosphatidylinositide 3'-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C.

    Tenzer A et al (2001) Cancer Res 61(22) : 8203-10.
    PubMedID: 11719451
  • PKC412 induces apoptosis through a caspase-dependent mechanism in human keloid-derived fibroblasts.

    Nakazono-Kusaba A et al (2004) Eur J Pharmacol 497(2) : 155-60.
    PubMedID: 15306200

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