Product overview

Name PKC-412
Alternative names CGP 41251; Midostaurin; 4'-N-benzoylstaurosporine; PKC412
Purity >96%
Description Broad spectrum protein kinase inhibitor
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Biological Data

Biological description Broad spectrum protein kinase inhibitor. Inhibits PKC (isoforms α, β and γ), Syk, FLK-1, PKA, c-kit, Akt, FLT3, VEGFR1, VEGFR2, EGFR and c-src. Also selectively blocks TNF-α production. Displays antitumor, antiproliferative and pro-apoptotic properties.

Solubility & Handling

Solubility overview Soluble in DMSO (15mg/ml) or MDC (10mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >96%
Chemical name Midostaurin; 4'-N-benzoylstaurosporine
Molecular Weight 570.64
Chemical structure PKC-412  [120685-11-2] Chemical Structure
Molecular Formula C35H30N4O4
CAS Number 120685-11-2
SMILES CO[C@]1(C)[C@@H]([C@H]2O[C@]1(C)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35)N(C)C(=O)c9ccccc9

References for PKC-412

References are publications that support the biological activity of the product
  • Effects of the kinase inhibitor CGP41251 (PKC 412) on lymphocyte activation and TNF-alpha production.

    Si MS et al (2005) Int Immunopharmacol 5(7-8) : 1141-9.
  • PKC412 induces apoptosis through a caspase-dependent mechanism in human keloid-derived fibroblasts.

    Nakazono-Kusaba A et al (2004) Eur J Pharmacol 497(2) : 155-60.
  • The phosphatidylinositide 3'-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C.

    Tenzer A et al (2001) Cancer Res 61(22) : 8203-10.
  • PKC412--a protein kinase inhibitor with a broad therapeutic potential.

    Fabbro D et al (2000) Anticancer Drug Des 15(1) : 17-28.

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