PNU 37883 hydrochloride

(HB1105)

Pack	Price	Qty
10mg	$115
50mg	$457

(HB1105)

Data

Product overview

Name
PNU 37883 hydrochloride
Short description
Selective vascular K_ATP channel antagonist
Biological description
Selective vascular K_ATP channel antagonist (IC₅₀ values are 15 and 6 µM for SUR2B/ K_ir6.2 and SUR2B/ K_ir6.1 channels respectively). Also K_ir6.2δ26 channel inhibitor (IC₅₀ = 5.0 µM). Displays no activity at cardiac, pancreatic or skeletal k_ATP channels. Displays diuretic properties.
Biological action
Antagonist
Purity
>99%
Citations
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Chemical name
N-Cyclohexyl-N'-tricyclo[3.3.1.13,7]dec-1-yl-4-morpholinecarboximidamide hydrochloride
Molecular Weight
381.98
Chemical structure
Molecular Formula
C₂₁H₃₅N₃O.HCl
CAS Number
57568-80-6

Storage instructions
room temperature (desiccate)
Solubility overview
soluble in DMSO (25mM) or ethanol (100mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Pharmacological Profile of U-37883A, a Channel Blocker of Smooth Muscle-Type ATP-Sensitive K Channels.
Teramoto N (2006) Cardiovasc Drug Rev 24(1) : 25-32.
PubMedID: 16939631
Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A.
Cui Y et al (2003) Br J Pharmacol 139(1) : 122-8.
PubMedID: 12746230
Molecular analysis of the subtype-selective inhibition of cloned KATP channels by PNU-37883A.
Kovalev H et al (2004) Br J Pharmacol 141(5) : 867-73.
PubMedID: 14757705

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