PNU 37883 hydrochloride

(HB1105)

Product overview

  • Name
    PNU 37883 hydrochloride
  • Short description
    Selective vascular KATP channel antagonist
  • Biological description
    Selective vascular KATP channel antagonist (IC50 values are 15 and 6 µM for SUR2B/ Kir6.2 and SUR2B/ Kir6.1 channels respectively). Also Kir6.2δ26 channel inhibitor (IC50 = 5.0 µM). Displays no activity at cardiac, pancreatic or skeletal kATP channels. Displays diuretic properties.
  • Biological action
    Antagonist
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    N-Cyclohexyl-N'-tricyclo[3.3.1.13,7]dec-1-yl-4-morpholinecarboximidamide hydrochloride
  • Molecular Weight
    381.98
  • Chemical structure
    PNU 37883 hydrochloride  [57568-80-6]
  • Molecular Formula
    C21H35N3O.HCl
  • CAS Number
    57568-80-6

Storing and Using Your Product

  • Storage instructions
    room temperature (desiccate)
  • Solubility overview
    soluble in DMSO (25mM) or ethanol (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for PNU 37883 hydrochloride

  • Pharmacological Profile of U-37883A, a Channel Blocker of Smooth Muscle-Type ATP-Sensitive K Channels.

    Teramoto N (2006) Cardiovasc Drug Rev 24(1) : 25-32.
    PubMedID: 16939631
  • Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A.

    Cui Y et al (2003) Br J Pharmacol 139(1) : 122-8.
    PubMedID: 12746230
  • Molecular analysis of the subtype-selective inhibition of cloned KATP channels by PNU-37883A.

    Kovalev H et al (2004) Br J Pharmacol 141(5) : 867-73.
    PubMedID: 14757705

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