Pack	Price	Qty
10mg	$115
50mg	$457

PNU 37883 hydrochloride

(HB1105)

Product overview

Name
PNU 37883 hydrochloride
Short description
Selective vascular K_ATP channel antagonist
Biological description
Selective vascular K_ATP channel antagonist (IC₅₀ values are 15 and 6 µM for SUR2B/ K_ir6.2 and SUR2B/ K_ir6.1 channels respectively). Also K_ir6.2δ26 channel inhibitor (IC₅₀ = 5.0 µM). Displays no activity at cardiac, pancreatic or skeletal k_ATP channels. Displays diuretic properties.
Biological action
Antagonist
Purity
>99%
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Chemical name
N-Cyclohexyl-N'-tricyclo[3.3.1.13,7]dec-1-yl-4-morpholinecarboximidamide hydrochloride
Molecular Weight
381.98
Chemical structure
Molecular Formula
C₂₁H₃₅N₃O.HCl
CAS Number
57568-80-6

Pharmacological Profile of U-37883A, a Channel Blocker of Smooth Muscle-Type ATP-Sensitive K Channels.
Teramoto N (2006) Cardiovasc Drug Rev 24(1) : 25-32.
PubMedID: 16939631
Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A.
Cui Y et al (2003) Br J Pharmacol 139(1) : 122-8.
PubMedID: 12746230
Molecular analysis of the subtype-selective inhibition of cloned KATP channels by PNU-37883A.
Kovalev H et al (2004) Br J Pharmacol 141(5) : 867-73.
PubMedID: 14757705