PNU 37883 hydrochloride
(HB1105)- Data
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Data
Product overview
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Name
PNU 37883 hydrochloride
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Short description
Selective vascular KATP channel antagonist
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Biological description
Selective vascular KATP channel antagonist (IC50 values are 15 and 6 µM for SUR2B/ Kir6.2 and SUR2B/ Kir6.1 channels respectively). Also Kir6.2δ26 channel inhibitor (IC50 = 5.0 µM). Displays no activity at cardiac, pancreatic or skeletal kATP channels. Displays diuretic properties.
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Biological action
Antagonist
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Purity
>99%
- Citations
Properties
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Chemical name
N-Cyclohexyl-N'-tricyclo[3.3.1.13,7]dec-1-yl-4-morpholinecarboximidamide hydrochloride
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Molecular Weight
381.98
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Chemical structure
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Molecular Formula
C21H35N3O.HCl
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CAS Number
57568-80-6
Storing and Using Your Product
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Storage instructions
room temperature (desiccate)
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Solubility overview
soluble in DMSO (25mM) or ethanol (100mM)
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Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for PNU 37883 hydrochloride
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Pharmacological Profile of U-37883A, a Channel Blocker of Smooth Muscle-Type ATP-Sensitive K Channels.
Teramoto N (2006) Cardiovasc Drug Rev 24(1) : 25-32.PubMedID: 16939631 -
Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A.
Cui Y et al (2003) Br J Pharmacol 139(1) : 122-8.PubMedID: 12746230 -
Molecular analysis of the subtype-selective inhibition of cloned KATP channels by PNU-37883A.
Kovalev H et al (2004) Br J Pharmacol 141(5) : 867-73.PubMedID: 14757705
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