Product overview

Name PNU 37883 hydrochloride
Purity >99%
Description Selective vascular KATP channel antagonist
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Biological Data

Biological description Selective vascular KATP channel antagonist (IC50 values are 15 and 6 µM for SUR2B/ Kir6.2 and SUR2B/ Kir6.1 channels respectively). Also Kir6.2δ26 channel inhibitor (IC50 = 5.0 µM). Displays no activity at cardiac, pancreatic or skeletal kATP channels. Displays diuretic properties.

Solubility & Handling

Storage instructions room temperature (desiccate)
Solubility overview Soluble in DMSO (25mM) or ethanol (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >99%
Chemical name N-Cyclohexyl-N'-tricyclo[3.3.1.13,7]dec-1-yl-4-morpholinecarboximidamide hydrochloride
Molecular Weight 381.98
Chemical structure PNU 37883 hydrochloride  [57568-80-6] Chemical Structure
Molecular Formula C21H35N3O.HCl
CAS Number 57568-80-6
PubChem identifier 64392
SMILES C1(CC3C2)CC2(/N=C(N5CCOCC5)/NC4CCCCC4)CC(C3)C1.Cl
InChiKey FZALCKUJYZCDOX-UHFFFAOYSA-N

References for PNU 37883 hydrochloride

References are publications that support the biological activity of the product
  • Pharmacological Profile of U-37883A, a Channel Blocker of Smooth Muscle-Type ATP-Sensitive K Channels.

    Teramoto N (2006) Cardiovasc Drug Rev 24(1) : 25-32.
  • Molecular analysis of the subtype-selective inhibition of cloned KATP channels by PNU-37883A.

    Kovalev H et al (2004) Br J Pharmacol 141(5) : 867-73.
  • Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A.

    Cui Y et al (2003) Br J Pharmacol 139(1) : 122-8.

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