PNU 74654

(HB0528)

Product overview

  • Name
    PNU 74654
  • Short description
    β-catenin inhibitor. Wnt pathway inhibitor.
  • Biological description
    β-catenin inhibitor (Kd = 450 nM). Blocks the interaction with T cell factor (TCF). Inhibits the Wnt/β-catenin pathway.
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    2-Phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydrazide
  • Molecular Weight
    320.34
  • Chemical structure
    PNU 74654  [113906-27-7]
  • Molecular Formula
    C19H16N2O3
  • CAS Number
    113906-27-7
  • PubChem identifier
    60119583
  • SMILES
    CC1=CC=C(O1)C=NNC(=O)C2=CC=CC=C2OC3=CC=CC=C3

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (100mM)

References for PNU 74654

  • Characterization of differential gene expression in adrenocortical tumors harboring beta-catenin (CTNNB1) mutations.

    Durand J et al (2011) J Clin Endocrinol Metab 96(7) : E1206-11.
    PubMedID: 21565795
  • Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening.

    Trosset JY et al (2006) Proteins 64(1) : 60-7.
    PubMedID: 16568448
  • Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.

    Wells JA et al (2007) Nature 450(7172) : 1001-9.
    PubMedID: 18075579

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