PP 1

(HB1334)

Order: HB1334

(HB1334)

Data

Product overview

Name
PP 1
Short description
Potent Src-family tyrosine kinase inhibitor
Biological description
Potent Src-family tyrosine kinase inhibitor. Selective for Lck and Fyn T over EGF-R, JAK2 and ZAP -70 (IC₅₀ values are 5 and 6 nM, 0.25, >50 and > 100 µM respectively). Also inhibits Kit, Bcr-Abl, c-Abl and MAP kinase p38. Shows anti-cancer, antiproliferative and apoptotic actions.
Biological action
Inhibitor
Purity
>99%
Citations
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Chemical name
1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Molecular Weight
281.36
Molecular Formula
C₁₆H₁₉N₅
CAS Number
172889-26-8

Storage instructions
+4°C (desiccate)
Solubility overview
soluble in DMSO (10mM) or ethanol (10mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation.
Hanke JH et al (1996) J Biol Chem 271(2) : 695-701.
PubMedID: 8557675
Structural basis for selective inhibition of Src family kinases by PP1.
Liu Y et al (1999) Chem Biol 6(9) : 671-8.
PubMedID: 10467133
The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases.
Tatton L et al (2003) J Biol Chem 278(7) : 4847-53.
PubMedID: 12475982
The Src family kinase inhibitors PP2 and PP1 effectively block TGF-beta1-induced cell migration and invasion in both established and primary carcinoma cells.
Bartscht T et al (2012) Cancer Chemother Pharmacol 70(2) : 221-30.
PubMedID: 22699812

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