PP 1
(HB1334)- Data
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Data
Product overview
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NamePP 1
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Short descriptionPotent Src-family tyrosine kinase inhibitor
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Biological descriptionPotent Src-family tyrosine kinase inhibitor. Selective for Lck and Fyn T over EGF-R, JAK2 and ZAP -70 (IC50 values are 5 and 6 nM, 0.25, >50 and > 100 µM respectively). Also inhibits Kit, Bcr-Abl, c-Abl and MAP kinase p38. Shows anti-cancer, antiproliferative and apoptotic actions.
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Biological actionInhibitor
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Purity>99%
- Citations
Properties
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Chemical name1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Molecular Weight281.36
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Molecular FormulaC16H19N5
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CAS Number172889-26-8
Storing and Using Your Product
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Storage instructions+4°C (desiccate)
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Solubility overviewsoluble in DMSO (10mM) or ethanol (10mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for PP 1
Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation.
Hanke JH et al (1996) J Biol Chem 271(2) : 695-701.PubMedID: 8557675Structural basis for selective inhibition of Src family kinases by PP1.
Liu Y et al (1999) Chem Biol 6(9) : 671-8.PubMedID: 10467133The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases.
Tatton L et al (2003) J Biol Chem 278(7) : 4847-53.PubMedID: 12475982The Src family kinase inhibitors PP2 and PP1 effectively block TGF-beta1-induced cell migration and invasion in both established and primary carcinoma cells.
Bartscht T et al (2012) Cancer Chemother Pharmacol 70(2) : 221-30.PubMedID: 22699812
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