PP 1

(HB1334)

Product overview

  • Name
    PP 1
  • Short description
    Potent Src-family tyrosine kinase inhibitor
  • Biological description
    Potent Src-family tyrosine kinase inhibitor. Selective for Lck and Fyn T over EGF-R, JAK2 and ZAP -70 (IC50 values are 5 and 6 nM, 0.25, >50 and > 100 µM respectively). Also inhibits Kit, Bcr-Abl, c-Abl and MAP kinase p38. Shows anti-cancer, antiproliferative and apoptotic actions.
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
  • Molecular Weight
    281.36
  • Molecular Formula
    C16H19N5
  • CAS Number
    172889-26-8

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    soluble in DMSO (10mM) or ethanol (10mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for PP 1

  • Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation.

    Hanke JH et al (1996) J Biol Chem 271(2) : 695-701.
    PubMedID: 8557675
  • Structural basis for selective inhibition of Src family kinases by PP1.

    Liu Y et al (1999) Chem Biol 6(9) : 671-8.
    PubMedID: 10467133
  • The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases.

    Tatton L et al (2003) J Biol Chem 278(7) : 4847-53.
    PubMedID: 12475982
  • The Src family kinase inhibitors PP2 and PP1 effectively block TGF-beta1-induced cell migration and invasion in both established and primary carcinoma cells.

    Bartscht T et al (2012) Cancer Chemother Pharmacol 70(2) : 221-30.
    PubMedID: 22699812

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