PP 2

(HB1335)

Product overview

  • Name
    PP 2
  • Short description
    Potent, selective Src-family tyrosine kinase inhibitor
  • Biological description
    Potent and selective Src-family tyrosine kinase inhibitor. Selective for Lck and Fyn T over EGF-R, JAK2 and ZAP -70 (IC50 values are 4 and 5 nM, 0.48, >50 and > 100 µM respectively). Also inhibits CSK, SAPK2a (p38), SAPK2b (p38β2) and CK1δ. Prevents β-adrenergic stimulation of the cardiac pacemaker. Shows anti-proliferative actions against cancer.
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    3-(4-chlorophenyl)1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
  • Molecular Weight
    301.78
  • Molecular Formula
    C15H16ClN5
  • CAS Number
    172889-27-9

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    soluble in DMSO (25mM, gentle warming) or ethanol (10mM, gentle warming)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for PP 2

  • Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation.

    Hanke JH et al (1996) J Biol Chem 271(2) : 695-701.
    PubMedID: 8557675
  • The specificities of protein kinase inhibitors: an update.

    Bain J et al (2003) Biochem J 371(Pt 1) : 199-204.
    PubMedID: 12534346
  • PP2 prevents β-adrenergic stimulation of cardiac pacemaker activity.

    Huang J et al (2014) J Cardiovasc Pharmacol 63(6) : 533-43.
    PubMedID: 24566462
  • Src family kinase inhibitor PP2 efficiently inhibits cervical cancer cell proliferation through down-regulating phospho-Src-Y416 and phospho-EGFR-Y1173.

    Kong L et al (2011) Mol Cell Biochem 348(1-2) : 11-9.
    PubMedID: 21052789

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