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Biological Data

Biological description Potent and selective Src-family tyrosine kinase inhibitor. Selective for Lck and Fyn T over EGF-R, JAK2 and ZAP -70 (IC50 values are 4 and 5 nM, 0.48, >50 and > 100 µM respectively). Also inhibits CSK, SAPK2a (p38), SAPK2b (p38β2) and CK1δ. Prevents β-adrenergic stimulation of the cardiac pacemaker. Shows anti-proliferative actions against cancer.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in DMSO (25mM, gentle warming) or ethanol (10mM, gentle warming)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >99%
Chemical name 3-(4-chlorophenyl)1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Molecular Weight 301.78
Molecular Formula C15H16ClN5
CAS Number 172889-27-9
PubChem identifier 4878
SMILES CC(C)(C)N1N=C(C2=C(N)N=CN=C12)C1=CC=C(Cl)C=C1
InChiKey PBBRWFOVCUAONR-UHFFFAOYSA-N

References for PP 2

References are publications that support the biological activity of the product
  • PP2 prevents β-adrenergic stimulation of cardiac pacemaker activity.

    Huang J et al (2014) J Cardiovasc Pharmacol 63(6) : 533-43.
  • Src family kinase inhibitor PP2 efficiently inhibits cervical cancer cell proliferation through down-regulating phospho-Src-Y416 and phospho-EGFR-Y1173.

    Kong L et al (2011) Mol Cell Biochem 348(1-2) : 11-9.
  • The specificities of protein kinase inhibitors: an update.

    Bain J et al (2003) Biochem J 371(Pt 1) : 199-204.
  • Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation.

    Hanke JH et al (1996) J Biol Chem 271(2) : 695-701.

4 Item(s)